{"id":"W2486690983","doi":"10.1093/eurheartj/ehw292","title":"No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies","year":2016,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Amarin Corporation; Regeneron Pharmaceuticals; Sanofi; Amgen; Pfizer; Eli Lilly and Company","keywords":"Alirocumab; Medicine; PCSK9; Incidence (geometry); Diabetes mellitus; Internal medicine; Endocrinology; Total cholesterol; Cholesterol; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01890731,0.002593048,0.01368683,0.001836727,0.0004094905,0.002881188,0.0009515252,0.001671756,0.00345418],"category_scores_gemma":[0.01741644,0.001504726,0.03946372,0.002110271,0.000581249,0.001508439,0.001422585,0.002156683,0.0004597181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009251531,"about_ca_system_score_gemma":0.001152633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001881738,"about_ca_topic_score_gemma":0.004919664,"domain_scores_codex":[0.9843006,0.008244866,0.003178295,0.002334366,0.001423465,0.0005184166],"domain_scores_gemma":[0.9860362,0.007672123,0.003284142,0.001550633,0.001105916,0.0003510599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1026996,0.00004370134,0.008615122,0.02118313,0.8535503,0.0001664232,0.00006513923,0.0006288221,0.001387365,0.0000865758,0.001385798,0.01018807],"study_design_scores_gemma":[0.02375991,0.002433555,0.02671834,0.001264599,0.941506,0.0001986348,0.00004434057,0.0004854019,0.0004290769,0.0002727296,0.002824993,0.00006242387],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2453274,0.7268961,0.006661877,0.0009013011,0.001996951,0.001262782,0.01050176,0.0004397,0.006012161],"genre_scores_gemma":[0.9416392,0.04797171,0.001725956,0.001558244,0.0006736792,0.0007841213,0.004005694,0.0001500367,0.00149143],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01890731,"threshold_uncertainty_score":0.09999257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518181106636608,"score_gpt":0.3139039350772275,"score_spread":0.2887221240108614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}