{"id":"W2486710394","doi":"10.1158/1538-7445.am2016-lb-057","title":"Abstract LB-057: 1-Benzylquinazoline-2,4(1H,3H)-diones as potent PARP inhibitors. SAR of the quinazoline group and in vivo efficacy of clinical candidate IMP4297","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact","funders":"","keywords":"Olaparib; Medicine; In vivo; Cancer; PARP inhibitor; Poly ADP ribose polymerase; Cancer research; Pharmacology; Quinazoline; Polymerase; Internal medicine; Enzyme; Stereochemistry; Biology; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002006773,0.0004214043,0.0003203484,0.0002579144,0.0001157236,0.0002361815,0.0004567627,0.0002261049,0.004427762],"category_scores_gemma":[0.00010726,0.0001335655,0.0002073273,0.0002778208,0.0001530356,0.000173079,0.0001691344,0.0007128029,0.001419391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002431529,"about_ca_system_score_gemma":0.000226009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312939,"about_ca_topic_score_gemma":0.001684684,"domain_scores_codex":[0.9999225,0.00001870692,0.000005577156,0.000009830759,0.00002396173,0.00001933068],"domain_scores_gemma":[0.999927,0.0000116016,0.00001348935,0.000007279518,0.00001625741,0.00002436807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001722072,0.0005390708,0.0005712307,0.0004275828,0.0000318969,0.0003091962,0.00006121164,0.00155769,0.9527925,0.0004983073,0.005099806,0.03638935],"study_design_scores_gemma":[0.002145408,0.02512669,0.01360048,0.0000825751,0.0001223895,0.00151343,0.00007180602,0.004069284,0.9025798,0.0002574071,0.05037141,0.00005948853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9212241,0.03153515,0.006415613,0.001468219,0.0003126048,0.0004221902,0.01075309,0.0005938307,0.02727523],"genre_scores_gemma":[0.9560665,0.01185956,0.003056582,0.0004813914,0.0000553712,0.0001421784,0.01142698,0.00005366582,0.0168577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004427762,"threshold_uncertainty_score":0.01481235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029621464948994,"score_gpt":0.4736846207194734,"score_spread":0.3707224742245741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}