{"id":"W2486785549","doi":"10.1101/059519","title":"Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Centre for Addiction and Mental Health","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; National Institutes of Health; Hjartavernd; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Université de Lille; Erasmus Medisch Centrum; Government of Canada; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Wellcome Trust; Centre hospitalier régional universitaire de Lille; Weston Brain Institute; Fulbright Canada; Fondation Brain Canada; National Institute on Aging; Alzheimer's Association","keywords":"Biology; Genome-wide association study; Immune system; Acquired immune system; Innate immune system; Amyotrophic lateral sclerosis; Disease; CD14; Parkinson's disease; Gene; Immunology; Genetics; Medicine; Pathology; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007207182,0.0003007952,0.0003700586,0.001114965,0.0002431536,0.0004880653,0.0001645732,0.0002463637,0.001197045],"category_scores_gemma":[0.0009567469,0.0001447998,0.0005041209,0.0007882479,0.0003439557,0.0002818878,0.0004422092,0.0002973452,0.0001162003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967925,"about_ca_system_score_gemma":0.0002399466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001239051,"about_ca_topic_score_gemma":0.001727946,"domain_scores_codex":[0.9995041,0.0001068486,0.00003806605,0.0002243755,0.00007736379,0.00004934774],"domain_scores_gemma":[0.9990894,0.0003243513,0.0003418703,0.0000827666,0.00009200424,0.00006970391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001531801,0.0001048323,0.6338746,0.0006454365,0.001626683,0.001191942,0.0007584079,0.001682293,0.3140253,0.002464358,0.0008285937,0.04126574],"study_design_scores_gemma":[0.00002384756,0.0001188988,0.987725,0.00003463446,0.0003182885,0.0006621791,0.0001413898,0.001307398,0.005379554,0.003025278,0.001248464,0.00001502387],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927098,0.00205145,0.002796125,0.00019874,0.00001152384,0.000007335886,0.001306215,0.00004858461,0.0008703326],"genre_scores_gemma":[0.995568,0.0005549861,0.002517491,0.0001269961,0.00001988947,0.000009666684,0.000814463,0.00001514736,0.000373404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239051,"threshold_uncertainty_score":0.004004478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04017301478731881,"score_gpt":0.2409009634184115,"score_spread":0.2007279486310927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}