{"id":"W2487905146","doi":"10.1158/1538-7445.am2016-3099","title":"Abstract 3099: <i>KRAS</i> and clinical context: Differential dynamic signaling output of <i>KRAS</i> mutant lung, colorectal and pancreatic cancer cell lines when exposed to targeted anticancer drugs","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"KRAS; Cancer research; Pancreatic cancer; Colorectal cancer; PI3K/AKT/mTOR pathway; Protein kinase B; Cancer; Medicine; MEK inhibitor; Cetuximab; Context (archaeology); Trametinib; Selumetinib; Internal medicine; Oncology; Biology; Signal transduction; MAPK/ERK pathway; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005801,0.0002748668,0.0003042627,0.0002136544,0.0001485131,0.0003345623,0.0001608701,0.0002846835,0.003744682],"category_scores_gemma":[0.000165832,0.000118459,0.0002700975,0.0003200022,0.000188235,0.000149737,0.0001389911,0.0004848327,0.0007435204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002458563,"about_ca_system_score_gemma":0.000231472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001281281,"about_ca_topic_score_gemma":0.001037256,"domain_scores_codex":[0.9997038,0.00005497392,0.00002936862,0.00007058179,0.00008279602,0.00005850107],"domain_scores_gemma":[0.9998995,0.00002960611,0.00002301352,0.00000989519,0.00002017772,0.00001787909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006160924,0.000118813,0.002108164,0.00005710029,0.00001363286,0.0001016988,0.00002692316,0.0001257491,0.9946415,0.00004288798,0.0002727349,0.001874643],"study_design_scores_gemma":[0.00003335579,0.001484231,0.04175876,0.000008060024,0.00003658696,0.0009451312,0.00008548086,0.001337958,0.9518073,0.0000363556,0.002456687,0.00001016365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935503,0.00071417,0.001338668,0.0001812315,0.00003727867,0.00004665312,0.002157567,0.00007842392,0.001895688],"genre_scores_gemma":[0.9922807,0.0004103211,0.001435878,0.00009995119,0.000009291466,0.00007529767,0.003210061,0.00002366901,0.002454806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003744682,"threshold_uncertainty_score":0.01252723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02526770676319688,"score_gpt":0.3472211273535846,"score_spread":0.3219534205903877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}