{"id":"W2488017628","doi":"10.1182/blood.v122.21.1942.1942","title":"Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (MM) Or Waldenstrom’s Macroglobulinemia (WM)","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ozmosis Research (Canada); University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Neutropenia; Gastroenterology; Febrile neutropenia; Internal medicine; Medicine; Dysgeusia; Pharmacodynamics; Nausea; Adverse effect; Refractory (planetary science); Vomiting; Phases of clinical research; Leukopenia; Pharmacokinetics; Pharmacology; Toxicity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004086325,0.0003738215,0.0006256152,0.0002346355,0.0001339806,0.0003012297,0.0002321722,0.0002489224,0.001431121],"category_scores_gemma":[0.0003005599,0.0001838179,0.000260345,0.0001655154,0.0003230568,0.0002961304,0.000178305,0.0007312427,0.0002340941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002861428,"about_ca_system_score_gemma":0.0003588184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003025765,"about_ca_topic_score_gemma":0.0012297,"domain_scores_codex":[0.9998608,0.00006270366,0.000009252328,0.00002208437,0.00001480064,0.0000303985],"domain_scores_gemma":[0.9998447,0.00003507248,0.00003359939,0.000009073676,0.000006383172,0.0000710933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2361766,0.03149204,0.05745997,0.001098802,0.0007494784,0.001275842,0.0009382096,0.006629634,0.3032243,0.0005958399,0.004191934,0.3561673],"study_design_scores_gemma":[0.05702504,0.7352488,0.1451768,0.00007254502,0.0005717617,0.001865631,0.0002442163,0.00313275,0.04915654,0.0002169908,0.007246109,0.00004278928],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998207,0.0007548018,0.0001095877,0.00005443723,0.000006834274,0.0001010825,0.0001708106,0.00002171168,0.0005738398],"genre_scores_gemma":[0.998439,0.0004863198,0.0001940009,0.00004559965,0.0000156639,0.00006806885,0.00025499,0.000003966025,0.0004923439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431121,"threshold_uncertainty_score":0.004787505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00481352103557048,"score_gpt":0.1942417280605303,"score_spread":0.1894282070249598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}