{"id":"W2488017628","doi":"10.1182/blood.v122.21.1942.1942","title":"Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (MM) Or Waldenstrom’s Macroglobulinemia (WM)","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ozmosis Research (Canada); University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Neutropenia; Gastroenterology; Febrile neutropenia; Internal medicine; Medicine; Dysgeusia; Pharmacodynamics; Nausea; Adverse effect; Refractory (planetary science); Vomiting; Phases of clinical research; Leukopenia; Pharmacokinetics; Pharmacology; Toxicity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009818387,0.0002733467,0.0004410191,0.0001073052,0.00005325837,0.00001570808,0.0001651303,0.0002271005,0.00004788739],"category_scores_gemma":[0.0001247259,0.0002219407,0.0000849104,0.000270757,0.0001344845,0.00002790452,0.00009372368,0.0002367823,0.000006715894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004251765,"about_ca_system_score_gemma":0.0001242049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004007044,"about_ca_topic_score_gemma":0.0006741892,"domain_scores_codex":[0.9984448,0.00007252886,0.0004344608,0.0004924759,0.0002284078,0.0003273061],"domain_scores_gemma":[0.9989224,0.00002094616,0.0003402933,0.0003824618,0.0002492741,0.00008463892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002604241,0.001677861,0.2833379,0.0001117614,0.0001131682,0.00002274957,0.0001548058,0.00002314883,0.7099463,0.000001796337,0.0009837465,0.001022554],"study_design_scores_gemma":[0.008835596,0.003032568,0.6229075,0.00009753295,0.00006147143,0.00002551994,0.0001353858,0.0001494289,0.3627916,0.000003766376,0.001622407,0.000337223],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990387,0.00002808979,0.000008572103,0.00003990849,0.0001091801,0.000551504,0.00006176162,0.00001578736,0.0001464914],"genre_scores_gemma":[0.9986221,0.00001935671,0.0009748371,0.00005767848,0.000107461,0.00001948931,0.00007585491,0.00005478108,0.00006847893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3471547,"threshold_uncertainty_score":0.9050478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00481352103557048,"score_gpt":0.1942417280605303,"score_spread":0.1894282070249598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}