{"id":"W2488182312","doi":"10.1038/icb.2016.45","title":"Purity of transferred CD8<sup>+</sup> T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP‐1","year":2016,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Cardiff University; Wellcome Trust; Wellcome","keywords":"Adoptive cell transfer; Cytotoxic T cell; CD8; Cancer research; Immunology; Immunotherapy; Biology; T cell; Cell biology; Immune system; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000762538,0.0005417572,0.0004678721,0.0003542973,0.0002929273,0.0008977763,0.000321435,0.0004796503,0.002280466],"category_scores_gemma":[0.0007038822,0.0002008752,0.0002131046,0.0002077155,0.000356283,0.0004352923,0.0004446511,0.001240545,0.001316971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002305182,"about_ca_system_score_gemma":0.0002644105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001410175,"about_ca_topic_score_gemma":0.0002402,"domain_scores_codex":[0.9992446,0.0002115092,0.00008814316,0.0001229591,0.0002326474,0.0001002364],"domain_scores_gemma":[0.9994177,0.0001810697,0.0001291981,0.0001155151,0.00009544742,0.00006116604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002728494,0.0002059741,0.000876377,0.00004951554,0.00001317429,0.00004530155,0.00004191123,0.0003125658,0.9881812,0.0005773284,0.0002177961,0.009206066],"study_design_scores_gemma":[0.00005430537,0.0005733873,0.002343629,0.00001726353,0.0000464899,0.0004055786,0.00002450439,0.001912722,0.9902395,0.0002864003,0.00409053,0.000005640661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9239027,0.003131538,0.05864251,0.0007504644,0.0001627394,0.0006448707,0.000636841,0.0007976879,0.01133048],"genre_scores_gemma":[0.982246,0.0005403027,0.01166423,0.0001809325,0.00006731159,0.0004880838,0.0006196075,0.0001693765,0.004024169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002280466,"threshold_uncertainty_score":0.007628918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459660981287091,"score_gpt":0.2839247773603377,"score_spread":0.2693281675474667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}