{"id":"W2488838881","doi":"10.18632/oncotarget.10546","title":"Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; Simon Fraser University; Women's College Hospital; University of Toronto","funders":"Medical Research and Materiel Command; National Cancer Institute; Cancer Council Victoria; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Rutgers Cancer Institute of New Jersey; Radboud Universiteit; Helse Vest; Cancer Research UK; University College London; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; U.S. Department of Defense; Lon V. Smith Foundation; Fred C. and Katherine B. Andersen Foundation; Minnesota Ovarian Cancer Alliance; Moffitt Cancer Center; Norges Forskningsråd; University of Cambridge; Kreftforeningen; Pomorski Uniwersytet Medyczny W Szczecinie; Deutsches Krebsforschungszentrum; National Center for Research Resources; Oak Foundation; Arvid Nilssons Fond; Francis Crick Institute; Mayo Foundation for Medical Education and Research; Oregon Health and Science University; Kræftens Bekæmpelse","keywords":"Ovarian cancer; RNA editing; Biology; Medicine; Genetics; Computational biology; RNA; Bioinformatics; Cancer; Oncology; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003844223,0.0001629456,0.0001712055,0.00003854365,0.0001353523,0.00005624721,0.0001211425,0.0001574522,0.0001876728],"category_scores_gemma":[0.0008792685,0.0001327834,0.00006311362,0.0001948497,0.00002529074,0.00001577569,0.00009035754,0.00004662059,0.00004253355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007319698,"about_ca_system_score_gemma":0.0001631335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002592996,"about_ca_topic_score_gemma":0.001684017,"domain_scores_codex":[0.9985204,0.0001383577,0.0003062389,0.0005333703,0.0001776683,0.0003239233],"domain_scores_gemma":[0.9989148,0.00004435891,0.0001474817,0.0003880928,0.0002622882,0.0002430297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007042963,0.00008568548,0.05418357,0.000005410722,0.0000449394,0.000005159717,0.0002263935,0.00006001067,0.9203264,0.0000247046,0.0227721,0.001561292],"study_design_scores_gemma":[0.01408438,0.0003946301,0.5098314,0.0002472623,0.00008920541,0.000002329836,0.0006797047,0.0008796491,0.2291993,0.0003436217,0.2433312,0.0009173279],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831471,0.000116666,0.007066396,0.005132971,0.0005802963,0.0003443751,0.002730315,0.00004233045,0.0008395849],"genre_scores_gemma":[0.9939572,0.00002088771,0.00165732,0.0008948484,0.001260733,0.00003399039,0.0006609777,0.00002476973,0.001489248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6911272,"threshold_uncertainty_score":0.5414748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009479959647011147,"score_gpt":0.2766711555528196,"score_spread":0.2671911959058084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}