{"id":"W2489240616","doi":"10.1182/blood.v126.23.2745.2745","title":"Ibrutinib Therapy in Rituximab-Refractory Patients with Waldenström's Macroglobulinemia: Initial Results from an International, Multicenter, Open-Label Phase 3 Substudy (iNNOVATETM)","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Royal Victoria Regional Health Centre; Royal Victoria Hospital; Dalhousie University","funders":"","keywords":"Ibrutinib; Rituximab; Medicine; Waldenstrom macroglobulinemia; Macroglobulinemia; Open label; Internal medicine; Refractory (planetary science); Lymphoplasmacytic Lymphoma; Phases of clinical research; Oncology; Clinical trial; Lymphoma; Leukemia; Multiple myeloma; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005513529,0.0003357187,0.0005348528,0.000227651,0.00005847638,0.0001626478,0.0008248917,0.0001922068,0.0001089964],"category_scores_gemma":[0.000541347,0.0002662184,0.0000311204,0.0004161843,0.0001633143,0.0006253579,0.0003359691,0.0005329108,0.0001094365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002371013,"about_ca_system_score_gemma":0.00319935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005154307,"about_ca_topic_score_gemma":0.00047508,"domain_scores_codex":[0.9965935,0.0001573388,0.0007511357,0.0008097935,0.001138662,0.0005495111],"domain_scores_gemma":[0.9975315,0.0001575615,0.000228327,0.0008955912,0.0007576807,0.0004293168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"nonrandomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2170819,0.4550577,0.2115948,0.00007560308,0.002174344,0.009297838,0.01134303,0.0000124003,0.003971631,0.00003914304,0.004014287,0.08533732],"study_design_scores_gemma":[0.9667381,0.004989042,0.01615873,0.0002338905,0.00008432585,0.00004216719,0.0003766107,0.001356041,0.005971636,0.00001975403,0.003654197,0.0003755116],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952856,0.0001323179,0.000004535033,0.0002895512,0.0003581663,0.00164211,0.0004957825,0.00007548005,0.001716494],"genre_scores_gemma":[0.9950836,0.00007992165,0.001576553,0.0005318876,0.0003678208,0.00007758806,0.002074691,0.00006981788,0.0001380699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7496561,"threshold_uncertainty_score":0.999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09222182345165915,"score_gpt":0.4035739745569185,"score_spread":0.3113521511052594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}