{"id":"W2489746138","doi":"10.1182/blood.v126.23.2944.2944","title":"Comparing Single-Agent Ibrutinib, Bendamustine Plus Rituximab (BR) and Ibrutinib Plus BR in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): An Indirect Comparison of the RESONATE and HELIOS Trials","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Ibrutinib; Chemoimmunotherapy; Bendamustine; Internal medicine; Rituximab; Clinical endpoint; Ofatumumab; Oncology; Placebo; Progression-free survival; Chronic lymphocytic leukemia; Surgery; Clinical trial; Leukemia; Lymphoma; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002224467,0.0008310877,0.003058905,0.0005580291,0.0002242882,0.0001553909,0.0005840384,0.0004092865,0.00002959262],"category_scores_gemma":[0.001422719,0.0005923708,0.0001858958,0.001170951,0.0007640927,0.0002524314,0.0006361777,0.000373368,0.00001772777],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.06917291,"about_ca_system_score_gemma":0.03574497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006180781,"about_ca_topic_score_gemma":0.001850125,"domain_scores_codex":[0.9929012,0.001025524,0.001980449,0.001251672,0.001500432,0.001340739],"domain_scores_gemma":[0.9956735,0.0007157231,0.0009457204,0.001335536,0.0004499193,0.0008795675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.09540025,0.01761946,0.7502418,0.01105673,0.005451767,0.001370716,0.03127855,0.01194117,0.004642844,0.0001422278,0.001020123,0.06983438],"study_design_scores_gemma":[0.7244861,0.007973906,0.09956817,0.003965983,0.002511458,0.0008323869,0.0008560179,0.1336879,0.02433617,0.00001896519,0.0005596303,0.001203231],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872653,0.008196625,0.000007585749,0.00003308935,0.0001498136,0.003517903,0.00005193663,0.0001542915,0.0006233923],"genre_scores_gemma":[0.9985697,0.0001446985,0.000347387,0.00006527385,0.0002192826,0.0001191961,0.0001424301,0.000146512,0.0002455614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6506736,"threshold_uncertainty_score":0.9996527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09230312178758879,"score_gpt":0.3083665010327774,"score_spread":0.2160633792451886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}