{"id":"W2489914332","doi":"10.1038/srep30384","title":"Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Children's Hospital of Pittsburgh; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Gilead Sciences","keywords":"Cytokine; Protein kinase B; PI3K/AKT/mTOR pathway; Cell biology; CD28; Phosphoinositide 3-kinase; Inflammation; Biology; T cell; Cancer research; Signal transduction; Chemistry; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001303978,0.0002178991,0.0003903062,0.0001975601,0.0001447366,0.00006365738,0.0001562704,0.0001397788,0.000552019],"category_scores_gemma":[0.0006966079,0.0001411261,0.0001367738,0.0004388503,0.0004846481,0.0002480553,0.0002195576,0.0001424271,0.00006849983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003075799,"about_ca_system_score_gemma":0.00306177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163429,"about_ca_topic_score_gemma":0.00003538165,"domain_scores_codex":[0.995649,0.00004488448,0.00083967,0.001256973,0.001712871,0.0004965668],"domain_scores_gemma":[0.9969652,0.00009753989,0.0004281196,0.001701716,0.0004858987,0.0003215369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002444051,0.0003984752,0.0005213406,0.00006975341,0.00003322807,0.0004871342,0.0001364648,0.000005026698,0.8932614,0.000002149819,0.1017005,0.003140036],"study_design_scores_gemma":[0.003967474,0.00009923553,0.0002127093,0.0006149624,0.00005815229,0.0004551818,0.00004423241,0.0001095346,0.9740915,0.000189868,0.0199937,0.0001634215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910605,0.0003345292,0.0004388422,0.0004888438,0.006384166,0.0008184238,0.0000981991,0.00008252641,0.0002939606],"genre_scores_gemma":[0.984772,0.00002394698,0.0006710279,0.00002057177,0.0002839272,0.00003640844,0.0001534722,0.00003958788,0.01399911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08170684,"threshold_uncertainty_score":0.8043109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01552325133203098,"score_gpt":0.268443003198051,"score_spread":0.2529197518660201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}