{"id":"W2489914332","doi":"10.1038/srep30384","title":"Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Children's Hospital of Pittsburgh; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Gilead Sciences","keywords":"Cytokine; Protein kinase B; PI3K/AKT/mTOR pathway; Cell biology; CD28; Phosphoinositide 3-kinase; Inflammation; Biology; T cell; Cancer research; Signal transduction; Chemistry; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043416,0.0003917797,0.0003189359,0.0002380457,0.0001331619,0.0002503552,0.0002391251,0.0002039609,0.001304635],"category_scores_gemma":[0.00009753945,0.0001150528,0.0002673301,0.0001994935,0.0001707843,0.0001630248,0.0001211392,0.0008542312,0.0002751765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002340532,"about_ca_system_score_gemma":0.0003388418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003008116,"about_ca_topic_score_gemma":0.0008762137,"domain_scores_codex":[0.9998525,0.00002697366,0.00002164437,0.00001864466,0.00003843189,0.00004171675],"domain_scores_gemma":[0.9999425,0.00001755247,0.00001196778,0.000009170139,0.000005930316,0.00001289703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000848509,0.0005116003,0.000138643,0.00008331725,0.00001220352,0.00004266136,0.00001405355,0.0002657577,0.9912266,0.0001545301,0.0001339028,0.006568317],"study_design_scores_gemma":[0.0002783899,0.00318317,0.001048497,0.000007029752,0.00002352918,0.0001462186,0.000009561976,0.001215794,0.9920848,0.00004772392,0.001951049,0.000004158513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990634,0.002854532,0.002750159,0.0001396124,0.0001064266,0.0001102443,0.0003723894,0.00009403645,0.002938705],"genre_scores_gemma":[0.9891643,0.00241469,0.004508689,0.0001144963,0.00004270952,0.0001735625,0.0007149645,0.0000185143,0.002848046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001304635,"threshold_uncertainty_score":0.004364431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01552325133203098,"score_gpt":0.268443003198051,"score_spread":0.2529197518660201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}