{"id":"W2490407052","doi":"10.1007/978-1-4939-4023-3_14","title":"Measuring Equilibrium Binding Constants for the WT1-DNA Interaction Using a Filter Binding Assay","year":2016,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"Zinc finger; Binding domain; Nucleic acid; DNA; Binding site; RNA; DNA-binding domain; DNA binding site; Binding constant; Equilibrium constant; Biology; LIM domain; Biophysics; Chemistry; Molecular biology; Genetics; Transcription factor; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003434263,0.002732644,0.002412247,0.002553248,0.001948747,0.001370331,0.004339472,0.002571347,0.009657795],"category_scores_gemma":[0.004095783,0.001741371,0.001756357,0.002218675,0.001069617,0.001550942,0.001012798,0.005012929,0.005023411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002737637,"about_ca_system_score_gemma":0.001760939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009515301,"about_ca_topic_score_gemma":0.01227195,"domain_scores_codex":[0.9944773,0.00129147,0.0002517255,0.001645025,0.001499684,0.0008348704],"domain_scores_gemma":[0.9936829,0.00424901,0.0002408036,0.0006141734,0.0007841341,0.000428992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002779153,0.0003706518,0.0004604848,0.0001688643,0.00008733776,0.00001614021,0.0001253564,0.0004011377,0.9930323,0.0005885499,0.0004845535,0.003986572],"study_design_scores_gemma":[0.00003640584,0.0004882769,0.003730709,0.00001813457,0.0001019497,0.00007548538,0.00006085677,0.006458156,0.9854649,0.000256037,0.003234885,0.00007410243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4165705,0.003243744,0.559095,0.000706343,0.0005217894,0.0012156,0.003677244,0.003348961,0.01162094],"genre_scores_gemma":[0.5852824,0.003923947,0.341431,0.0007406749,0.0001772577,0.003617513,0.01516336,0.0009211776,0.04874262],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.009657795,"threshold_uncertainty_score":0.03230858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06750895039338425,"score_gpt":0.391788538779868,"score_spread":0.3242795883864837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}