{"id":"W2490643784","doi":"10.1158/1538-7445.am2016-1319","title":"Abstract 1319: A novel formulation of CX-5461, a small-molecule inhibitor of rRNA synthesis, and its use for treatment of acute myeloid leukemia models","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"In vivo; Bioavailability; Pharmacokinetics; Chemistry; Pharmacology; Dosing; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001248024,0.0002779175,0.0001679124,0.0001566035,0.0001105111,0.0001437857,0.0002167211,0.0003376739,0.00114778],"category_scores_gemma":[0.00006120167,0.00009889607,0.0001397505,0.00007782879,0.0001151846,0.0001762184,0.0001218745,0.0003965603,0.0003179999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002161359,"about_ca_system_score_gemma":0.0001802319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006059321,"about_ca_topic_score_gemma":0.0006792552,"domain_scores_codex":[0.9999461,0.000007805368,0.000004902035,0.00001397679,0.00001900624,0.000008209919],"domain_scores_gemma":[0.9999655,0.000003645752,0.00001149463,0.000001958696,0.000006578714,0.00001087938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007995751,0.00006120594,0.00001857243,0.00004727144,0.000003432771,0.00003394544,0.000005215853,0.0001292977,0.9963229,0.0001034726,0.0001175006,0.003077226],"study_design_scores_gemma":[0.00006459251,0.00121713,0.0006165032,0.00000784147,0.00002241554,0.0002053366,0.000005493322,0.001721678,0.9898185,0.0000332455,0.006281012,0.000006307116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731512,0.004350176,0.01643911,0.0003695872,0.0001901309,0.0002491699,0.0006650375,0.0002799796,0.004305586],"genre_scores_gemma":[0.9753264,0.002401305,0.01351558,0.000110874,0.00004607721,0.0001609489,0.0006377886,0.00003377807,0.007767159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00114778,"threshold_uncertainty_score":0.003839672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1064700713630481,"score_gpt":0.3607874416196003,"score_spread":0.2543173702565522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}