{"id":"W2490801415","doi":"10.1152/ajpcell.00125.2016","title":"The ubiquitin proteasome system in atrophying skeletal muscle: roles and regulation","year":2016,"lang":"en","type":"review","venue":"American Journal of Physiology-Cell Physiology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Government of Canada","keywords":"Myogenesis; Ubiquitin; Proteasome; Cell biology; Biology; Autophagy; Anabolism; Wasting; Muscle atrophy; Catabolism; Skeletal muscle; Protein degradation; mTORC1; Signal transduction; Myocyte; Gene; PI3K/AKT/mTOR pathway; Genetics; Biochemistry; Endocrinology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005298972,0.0005926789,0.001915373,0.0001973656,0.0002188978,0.00001706391,0.0006960018,0.0004220225,0.000008969077],"category_scores_gemma":[0.0001056735,0.0003572611,0.0006064868,0.0002307145,0.001460243,0.00001514705,0.000302438,0.0006091325,0.00001601656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006082964,"about_ca_system_score_gemma":0.0003787775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001703369,"about_ca_topic_score_gemma":0.000008024655,"domain_scores_codex":[0.9959238,0.001459919,0.001156027,0.0006835057,0.0001395351,0.0006372716],"domain_scores_gemma":[0.99651,0.0003465879,0.002251738,0.0006059437,0.000152512,0.0001332638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003775798,0.0001068979,0.000003996789,0.001822188,0.0003069639,0.000004442522,0.00003413667,0.00003449059,0.3929516,0.000243661,0.0003056524,0.6038083],"study_design_scores_gemma":[0.002047107,0.004885403,0.003930105,0.004417168,0.0004200206,0.0002446069,0.0006945366,0.00001766521,0.0009795323,0.001128572,0.9799287,0.001306607],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1170485,0.8818238,0.00002243639,0.00004848526,0.0003677041,0.0005413968,0.00002452309,0.00001190895,0.0001112838],"genre_scores_gemma":[0.2583905,0.7404901,0.00007416407,0.00005274139,0.0007727706,0.0000705057,0.00004709546,0.00005859192,0.00004349877],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.979623,"threshold_uncertainty_score":0.9998879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006860219281722845,"score_gpt":0.2527329225899679,"score_spread":0.245872703308245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}