{"id":"W2491027990","doi":"10.1158/1538-7445.am2016-2921","title":"Abstract 2921: The retinoblastoma protein regulates hypoxia-inducible factor-1α-mediated transcriptional programs, tumor cell invasiveness, tumor growth and metastasis in human breast cancer cells","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Simon Fraser University","funders":"","keywords":"Aryl hydrocarbon receptor nuclear translocator; Cancer research; Biology; Gene knockdown; Retinoblastoma; Retinoblastoma protein; Small hairpin RNA; PI3K/AKT/mTOR pathway; Carcinogenesis; SNAI1; Metastasis; Epithelial–mesenchymal transition; Transcription factor; Molecular biology; Cell; Cancer; Signal transduction; Gene; Cell biology; Cell cycle; Aryl hydrocarbon receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103918,0.0003988055,0.0004933688,0.0003660514,0.0002675831,0.0002972367,0.0001249871,0.0001856974,0.001637185],"category_scores_gemma":[0.0001023387,0.0001213176,0.0002800401,0.0005065785,0.0001079404,0.0001280076,0.0001438729,0.0002960847,0.001086886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003373472,"about_ca_system_score_gemma":0.0002823521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211479,"about_ca_topic_score_gemma":0.001315997,"domain_scores_codex":[0.9998098,0.00001741775,0.00001260118,0.00004084548,0.00008735901,0.00003193155],"domain_scores_gemma":[0.9999478,0.000005936186,0.00001611384,0.000004447677,0.00001388556,0.00001192596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009372667,0.00001597026,0.0003079833,0.00004838445,0.000005061305,0.00003735279,0.000008286053,0.00004833782,0.9981475,0.00001656474,0.0001253717,0.001145382],"study_design_scores_gemma":[0.00002073396,0.0002964574,0.03866497,0.00001359659,0.00005615891,0.0005226457,0.0000429882,0.001223937,0.9499398,0.0000522086,0.0091552,0.00001123569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706189,0.01241939,0.003883064,0.0002832788,0.0001249295,0.0000948223,0.009158151,0.0003198474,0.003097595],"genre_scores_gemma":[0.9575005,0.005944637,0.004639424,0.000212676,0.00006302226,0.0001479039,0.01844077,0.00009731483,0.01295386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001637185,"threshold_uncertainty_score":0.005476952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03555327160495585,"score_gpt":0.303042263464484,"score_spread":0.2674889918595281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}