{"id":"W2492265454","doi":"10.1242/bio.019943","title":"Critical importance of appropriate fixation conditions for faithful imaging of receptor microclusters","year":2016,"lang":"en","type":"article","venue":"Biology Open","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wolfson College, University of Oxford; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; European Commission; Medical Research Council; Directorate for Biological Sciences; University of Oxford; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Fixation (population genetics); Computational biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001958085,0.0006309078,0.0006755508,0.0004559059,0.0005599524,0.0009187396,0.0004812841,0.0008457977,0.001500651],"category_scores_gemma":[0.003187545,0.0004419336,0.0002015165,0.0002715419,0.0007534203,0.001108187,0.0007124208,0.0008632471,0.0007644209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004441875,"about_ca_system_score_gemma":0.0005755359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005885698,"about_ca_topic_score_gemma":0.001059035,"domain_scores_codex":[0.9989839,0.0002738551,0.0001228909,0.0002435764,0.0002546723,0.000121027],"domain_scores_gemma":[0.9982744,0.0008811706,0.0002357734,0.0002315137,0.0002853248,0.00009178501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003442131,0.00001151808,0.0001595412,0.0001391965,0.000004530478,0.00008646421,0.00005153057,0.0001298161,0.9967349,0.000386624,0.00007705328,0.002184361],"study_design_scores_gemma":[0.00002095731,0.0001549028,0.003837032,0.00008567655,0.00003169265,0.0006384416,0.0001661677,0.001961537,0.9846305,0.0008485191,0.007590924,0.00003359147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7338871,0.01892359,0.2363791,0.002495651,0.0008501016,0.0006166375,0.0008729489,0.0005690925,0.005405778],"genre_scores_gemma":[0.8464611,0.01152058,0.1377633,0.0004099263,0.0001934596,0.0007519011,0.0008669883,0.0003948798,0.001637896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001958085,"threshold_uncertainty_score":0.01035547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481087366264056,"score_gpt":0.3209649817936281,"score_spread":0.3061541081309875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}