{"id":"W2492981070","doi":"10.1158/1538-7445.am2016-3019","title":"Abstract 3019: High throughput drug screening identified spleen tyrosine kinase as a novel therapeutic target in head and neck cancer with potent in vitro and in vivo activity","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; London Health Sciences Centre","funders":"","keywords":"Syk; Head and neck squamous-cell carcinoma; Cancer research; In vivo; Cancer; Medicine; Cell culture; Tyrosine kinase; Pharmacology; Head and neck cancer; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002495086,0.0005532074,0.0005865026,0.0004160031,0.0001894123,0.0003787532,0.0002751597,0.0003487279,0.002871478],"category_scores_gemma":[0.0001377141,0.0001554192,0.0003534684,0.0003717843,0.000157264,0.0001607099,0.0002170323,0.000441714,0.0009084607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004352537,"about_ca_system_score_gemma":0.000545333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001144004,"about_ca_topic_score_gemma":0.003291371,"domain_scores_codex":[0.9998759,0.000016957,0.000009588837,0.0000273786,0.00004823003,0.00002195732],"domain_scores_gemma":[0.9999243,0.00001290111,0.00001419663,0.000006968207,0.00002518554,0.00001649394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004422385,0.0003157775,0.0009834649,0.000245932,0.00005176381,0.0001598056,0.00001934713,0.001171285,0.9827591,0.00009755053,0.001109423,0.01264426],"study_design_scores_gemma":[0.0002110994,0.003372203,0.006565773,0.0000257508,0.0001416957,0.000675988,0.00002688088,0.00284037,0.9786965,0.00006875784,0.007352725,0.00002224976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701255,0.008459095,0.006999486,0.0003854762,0.00006015625,0.0004643294,0.006613844,0.000501244,0.006390776],"genre_scores_gemma":[0.9702402,0.005493276,0.007582843,0.0002552296,0.00001633532,0.0002200317,0.007635565,0.00006379115,0.008492721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002871478,"threshold_uncertainty_score":0.009606063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06321611745639652,"score_gpt":0.3782479406194234,"score_spread":0.3150318231630269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}