{"id":"W2493288410","doi":"10.1093/annonc/mdw237.01","title":"LBA-01 Safety and efficacy of cobimetinib (cobi) and atezolizumab (atezo) in a Phase 1b study of metastatic colorectal cancer (mCRC)","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Atezolizumab; Colorectal cancer; Oncology; Internal medicine; Rash; Blockade; Cancer; Gastroenterology; Nivolumab; Immunotherapy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001602416,0.00082864,0.001753897,0.0003393898,0.0003532875,0.001188309,0.0007982107,0.001248746,0.003867594],"category_scores_gemma":[0.001386092,0.0006204652,0.001598743,0.0003444831,0.0008529445,0.0008400705,0.0003563854,0.004394232,0.001004128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009093799,"about_ca_system_score_gemma":0.001203211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001260599,"about_ca_topic_score_gemma":0.003809744,"domain_scores_codex":[0.9995078,0.0002332987,0.00002787559,0.00006384184,0.00005390273,0.0001133462],"domain_scores_gemma":[0.99915,0.0001701836,0.0001607251,0.00006899596,0.00006354884,0.0003864711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8058605,0.01990734,0.007634257,0.000668788,0.002014577,0.0001833861,0.0001948058,0.001852624,0.03851417,0.0003532321,0.005758598,0.1170578],"study_design_scores_gemma":[0.6364836,0.3148612,0.0320676,0.00006963867,0.001597639,0.0005720796,0.00008620519,0.001874958,0.005943997,0.0002526725,0.006134837,0.00005544761],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923837,0.003141332,0.0002167798,0.0007761726,0.000121477,0.0003382556,0.001110577,0.00008173289,0.001829972],"genre_scores_gemma":[0.9912716,0.001670008,0.0007133149,0.0007757639,0.0001435585,0.0004300781,0.002748844,0.00003181464,0.002215041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003867594,"threshold_uncertainty_score":0.01293838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0880581425312575,"score_gpt":0.4344553581050803,"score_spread":0.3463972155738228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}