{"id":"W2493713544","doi":"10.1128/jvi.01078-16","title":"ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Wake Forest School of Medicine; Mechanobiology Institute, Singapore; National Institutes of Health; Cancer Prevention and Research Institute of Texas; Cancer Research Institute","keywords":"Biology; Ubiquitin ligase; VP40; Ebola virus; NEDD4; Ebolavirus; Budding; Ubiquitin; Virology; Ubiquitin-Protein Ligases; Virus; Cell biology; Filoviridae; Zinc finger; Genetics; Viral disease; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004829855,0.0001124135,0.0003498168,0.0003936963,0.00005870269,0.00001779063,0.0001010597,0.00009117177,0.0005059004],"category_scores_gemma":[0.0002397935,0.00005850177,0.00009710639,0.000172831,0.00007850936,0.0001460914,0.00006162853,0.000325204,0.0001434852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050097,"about_ca_system_score_gemma":0.0001190935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003410212,"about_ca_topic_score_gemma":0.00004541346,"domain_scores_codex":[0.9988522,0.00008337459,0.0003711242,0.000136236,0.0002381728,0.0003189243],"domain_scores_gemma":[0.9989065,0.0001389181,0.0001746529,0.0001626436,0.0002929094,0.0003243627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002403766,0.0001332796,0.001928698,0.00001204819,0.0001116539,0.0007732837,0.000118703,0.00001258874,0.9626404,0.0001092486,0.004006059,0.02775025],"study_design_scores_gemma":[0.005750277,0.01090508,0.05447894,0.0007440507,0.0001558624,0.01239623,0.0001193616,0.0000609517,0.8392688,0.0003237358,0.07557663,0.000220059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822698,0.00006800293,0.001912402,0.01385014,0.0001784366,0.0001088015,0.000002949471,0.00001157869,0.001597944],"genre_scores_gemma":[0.9954302,0.00009045967,0.0005993344,0.001437951,0.000525216,0.000003365267,3.678774e-7,0.00002017777,0.001892905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1233716,"threshold_uncertainty_score":0.5539255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533108232537039,"score_gpt":0.3220623174343736,"score_spread":0.3067312351090032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}