{"id":"W2493838264","doi":"10.1038/srep30498","title":"Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Montréal; Academy of Finland; Helsingin Yliopisto","keywords":"Stress granule; Internalization; Hyperphosphorylation; Cell biology; Extracellular; Cytosol; RNA; Tau protein; Cell; Phosphorylation; Chemistry; Biology; Biochemistry; Alzheimer's disease; Medicine; Pathology; Disease; Translation (biology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404695,0.0003711152,0.0004716921,0.0001402728,0.0001169743,0.0004033889,0.0001519695,0.0003258198,0.00148434],"category_scores_gemma":[0.0001402926,0.000115153,0.000273095,0.00007872669,0.0002661049,0.000201359,0.0002697553,0.0007396596,0.0003635705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002462268,"about_ca_system_score_gemma":0.0001453418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002093319,"about_ca_topic_score_gemma":0.0002773164,"domain_scores_codex":[0.9998362,0.000030413,0.0000152305,0.00003330974,0.00004550844,0.00003927381],"domain_scores_gemma":[0.9998479,0.00003325188,0.00003702582,0.00003392577,0.00001384993,0.00003406391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005711305,0.00001425527,0.00006270662,0.00001549543,0.00000269167,0.00004657921,0.00001844843,0.00002301988,0.9991253,0.00007081547,0.00001221429,0.0005512738],"study_design_scores_gemma":[0.00001089175,0.0003471993,0.001989028,0.000005096531,0.00001052681,0.0002129181,0.00002146821,0.0003868264,0.9960372,0.00004709816,0.0009289107,0.000002752056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993141,0.00143587,0.003397274,0.00009649444,0.00005820561,0.0000319365,0.00007904669,0.0001234322,0.001636665],"genre_scores_gemma":[0.9945816,0.0007893502,0.002038164,0.00004854512,0.00002150158,0.00002144085,0.0001189875,0.00003067917,0.002349696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00148434,"threshold_uncertainty_score":0.004965603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009389511293837322,"score_gpt":0.254443609761165,"score_spread":0.2450540984673277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}