{"id":"W2493838264","doi":"10.1038/srep30498","title":"Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Montréal; Academy of Finland; Helsingin Yliopisto","keywords":"Stress granule; Internalization; Hyperphosphorylation; Cell biology; Extracellular; Cytosol; RNA; Tau protein; Cell; Phosphorylation; Chemistry; Biology; Biochemistry; Alzheimer's disease; Medicine; Pathology; Disease; Translation (biology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001081554,0.00007691969,0.0001074185,0.00004448938,0.00008263752,0.00006790368,0.00007098156,0.00004169637,0.00001089438],"category_scores_gemma":[0.0002753041,0.00005253055,0.00003782416,0.0000689873,0.0001459277,0.00001334374,0.0001252748,0.0000263631,8.923211e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000111063,"about_ca_system_score_gemma":0.00003344062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004761015,"about_ca_topic_score_gemma":0.00007773624,"domain_scores_codex":[0.9988083,0.00007372993,0.0003081871,0.0003769011,0.0002330198,0.0001998217],"domain_scores_gemma":[0.9991568,0.00001595244,0.0001513934,0.000371682,0.0001800099,0.0001241236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002317348,0.00002546585,0.01011239,0.00005653483,0.000006955581,0.00000726316,0.0001342271,7.797968e-7,0.9818588,0.000001201475,0.001418423,0.006354799],"study_design_scores_gemma":[0.0001243355,0.00005802813,0.0003356151,0.00008709214,0.00000280413,0.00001491618,0.0001257597,0.0000307414,0.9980016,0.00006615535,0.00108433,0.00006860086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971681,0.00008959826,0.002042114,0.00009361454,0.0002678749,0.0002362923,0.00003630491,0.000006447468,0.00005965977],"genre_scores_gemma":[0.9990127,0.00001153498,0.0001878368,0.000006061342,0.00001938104,0.000007137924,0.00003643116,0.000005896622,0.0007129819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01614283,"threshold_uncertainty_score":0.2142134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009389511293837322,"score_gpt":0.254443609761165,"score_spread":0.2450540984673277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}