{"id":"W2494270784","doi":"10.3389/fgene.2016.00142","title":"Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan","year":2016,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Caloric theory; Genome; Epigenetics; Nutraceutical; Biology; Function (biology); Malnutrition; Genetics; Calorie restriction; Gene; Bioinformatics; Medicine; Biochemistry; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005289564,0.0007740666,0.001026298,0.001705748,0.0003279186,0.001067628,0.0007048929,0.0012546,0.004509979],"category_scores_gemma":[0.0006933698,0.0002243148,0.0004085053,0.001597705,0.000646429,0.001539961,0.0008632088,0.002039633,0.002872659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006415573,"about_ca_system_score_gemma":0.0009189567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007627942,"about_ca_topic_score_gemma":0.001207198,"domain_scores_codex":[0.9998451,0.00002385563,0.00002260467,0.00003489374,0.0000555265,0.00001789917],"domain_scores_gemma":[0.9997693,0.00008580854,0.00003032726,0.00001253421,0.00007259677,0.00002952737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009037306,0.00007609819,0.0002247184,0.01293029,0.00007707213,0.0001650913,0.00009319452,0.0003007461,0.005724637,0.01329805,0.03525386,0.9317659],"study_design_scores_gemma":[0.000006904761,0.0000586301,0.0004373121,0.001497732,0.00003900076,0.0005505095,0.00004300369,0.00004691343,0.0009488779,0.00298372,0.9933735,0.00001380272],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001828824,0.9963279,0.000341875,0.0006347657,0.0004223775,0.000005237124,0.00003351377,0.00001977378,0.002031613],"genre_scores_gemma":[0.001081754,0.9965539,0.0003372156,0.0002527221,0.0001953168,0.000008262756,0.00003834092,0.000003989827,0.001528475],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004509979,"threshold_uncertainty_score":0.01508743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516075072847245,"score_gpt":0.2619197656039008,"score_spread":0.2467590148754283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}