{"id":"W2494361622","doi":"10.1158/1538-7445.am2016-ct147","title":"Abstract CT147: Phase I studies of AZD1208, a PIM kinase inhibitor, in patients with recurrent or refractory acute myelogenous leukemia or advanced solid tumors","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Medicine; Tolerability; Nausea; Rash; Vomiting; Internal medicine; Gastroenterology; Refractory (planetary science); Lethargy; Progressive disease; Leukemia; Chemotherapy; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001060532,0.0009180331,0.001708559,0.0004220122,0.0003038374,0.0006415069,0.0005966731,0.0006753574,0.002361435],"category_scores_gemma":[0.0008240384,0.0003173641,0.0009850416,0.000440825,0.0004503778,0.0004805523,0.0002582523,0.002175165,0.0005722432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006246015,"about_ca_system_score_gemma":0.0008232916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007583058,"about_ca_topic_score_gemma":0.001627269,"domain_scores_codex":[0.9996809,0.0001600152,0.00002443444,0.00003783873,0.00003361277,0.00006324991],"domain_scores_gemma":[0.9996204,0.00008564356,0.0000744385,0.00003180162,0.00003309965,0.0001544736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3947168,0.04607509,0.02141125,0.002178814,0.002188018,0.001685619,0.0007075896,0.005734551,0.2605125,0.0007698486,0.01261743,0.2514025],"study_design_scores_gemma":[0.2541096,0.6717497,0.03751761,0.0000808224,0.0008021527,0.001883716,0.00009759684,0.00349338,0.02185925,0.0002586574,0.008093984,0.00005358163],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914352,0.003312975,0.0005808888,0.0004273645,0.00008206565,0.001210694,0.001080245,0.0001409086,0.00172965],"genre_scores_gemma":[0.9899002,0.002144612,0.001803782,0.0006371848,0.000146853,0.001178544,0.002829448,0.00003242618,0.001327119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002361435,"threshold_uncertainty_score":0.007899821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08981200097409352,"score_gpt":0.4508240963214299,"score_spread":0.3610120953473364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}