{"id":"W2494641791","doi":"10.1158/1538-7445.am2016-2963","title":"Abstract 2963: VB7-756: a Her2-specific diabody armed with deBouganin, a plant toxin with a distinct MOA","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Furin; Cytotoxic T cell; Chemistry; Molecular biology; Linker; Protease; Potency; Cell culture; Cancer cell; Diphtheria toxin; In vitro; Cancer; Toxin; Biology; Biochemistry; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000704804,0.0003311072,0.0004161763,0.0002269946,0.0004750967,0.00007270574,0.0006101604,0.0002582196,0.005474524],"category_scores_gemma":[0.00006198933,0.0001772743,0.00006947241,0.0004074798,0.0008156623,0.0001720875,0.0001551056,0.0007796322,0.001094656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003010087,"about_ca_system_score_gemma":0.0004914473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007175404,"about_ca_topic_score_gemma":0.001233181,"domain_scores_codex":[0.9971398,0.000254727,0.0003058613,0.0007441327,0.0002550266,0.001300431],"domain_scores_gemma":[0.9983707,0.0003968541,0.0001058601,0.0007431993,0.0002718842,0.0001114824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002935934,0.0002215096,0.001656221,0.00003622704,0.0002439045,0.0001344603,0.0004984922,9.730612e-7,0.9685453,0.001201223,0.00904187,0.01548394],"study_design_scores_gemma":[0.005826722,0.001769662,0.03270227,0.0008797315,0.00002048996,0.0001424052,0.0007560814,4.243274e-7,0.6469064,0.0002650605,0.3100957,0.0006350666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909378,0.003682289,0.0004622296,0.001101722,0.0003047323,0.0008315364,0.0003806271,0.0001219961,0.002177117],"genre_scores_gemma":[0.9902758,0.0008771813,0.00009330679,0.00006976144,0.0001232191,0.0005975067,0.00004982744,0.00007759999,0.007835825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3216389,"threshold_uncertainty_score":0.9996831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03967782088522171,"score_gpt":0.3057539231138351,"score_spread":0.2660761022286134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}