{"id":"W2494695673","doi":"10.1083/jcb.201605090","title":"BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers","year":2016,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Eye Institute; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; National Institutes of Health; Canadian Institutes of Health Research; Wellcome; Université de Recherche Paris Sciences et Lettres; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Wellcome Trust; University of Pennsylvania; Labex CelTisPhyBio; Infrastructures en Biologie Santé et Agronomie; Centre National de la Recherche Scientifique","keywords":"Melanosome; Rab; Endosome; Cell biology; Endomembrane system; Lipid bilayer fusion; SNARE complex; Transport protein; Biology; Organelle; Chemistry; GTPase; Biochemistry; Membrane; Golgi apparatus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204024,0.0002595707,0.0002036556,0.0002657525,0.0002639045,0.0004632593,0.0002299941,0.0004609327,0.001238395],"category_scores_gemma":[0.0002175888,0.0002567588,0.0002953919,0.0001184258,0.0004745138,0.000356608,0.0004488531,0.0006068043,0.0004246542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000722469,"about_ca_system_score_gemma":0.0003366261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001808178,"about_ca_topic_score_gemma":0.002278513,"domain_scores_codex":[0.9998294,0.00002104404,0.00001250071,0.00003842496,0.00003950856,0.00005906806],"domain_scores_gemma":[0.9998032,0.00002556954,0.0000711417,0.00001414856,0.00002619644,0.00005964588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001632285,0.00001110944,0.0006549527,0.00001249069,0.000004160089,0.00009240397,0.00002716311,0.00005485237,0.9980797,0.0003334619,0.00003134558,0.0005352307],"study_design_scores_gemma":[0.00006868954,0.0001454749,0.05732306,0.00001420374,0.00002907251,0.0008477381,0.0001795036,0.004098239,0.934341,0.0003481331,0.002587056,0.00001773039],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976844,0.0006368236,0.0008107121,0.00005737507,0.000008137399,0.000007348423,0.00009861727,0.00004204044,0.0006546337],"genre_scores_gemma":[0.9979073,0.0002108328,0.0005215781,0.00003227007,0.000002627631,0.00001761318,0.0001306727,0.00002967541,0.001147433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808178,"threshold_uncertainty_score":0.005241871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004806926958385819,"score_gpt":0.218473533737143,"score_spread":0.2136666067787572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}