{"id":"W2494938857","doi":"10.1016/j.bmc.2016.07.026","title":"Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; American Lebanese Syrian Associated Charities; Institute for Catastrophic Loss Reduction; American Cancer Society","keywords":"Chemistry; Protein subunit; Small molecule; Clonogenic assay; DNA; Cisplatin; Biochemistry; Molecular biology; In vitro; Biology; Chemotherapy; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002973674,0.0001415851,0.0001384299,0.00001049651,0.00006235531,0.00000395484,0.0004479591,0.0001721058,0.00005508392],"category_scores_gemma":[0.0006200409,0.00007596499,0.0001821103,0.0001418058,0.0002039658,0.000004188628,0.0002254997,0.00009556442,0.000003646091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004962564,"about_ca_system_score_gemma":0.0001329614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009454428,"about_ca_topic_score_gemma":0.000009992776,"domain_scores_codex":[0.9988127,0.0000446638,0.0004268028,0.0003043326,0.0002627077,0.0001488133],"domain_scores_gemma":[0.998484,0.00001325964,0.0004398382,0.0008738454,0.0001466905,0.00004240991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004687343,0.00005407765,0.0004065412,0.000140085,0.00003532716,4.127556e-7,0.00003002564,7.970573e-8,0.998356,0.00001312013,0.0007204356,0.0001969793],"study_design_scores_gemma":[0.0003460042,0.00005496269,0.0009322274,0.0003238759,0.0000402254,0.00002264426,0.0000935627,0.000003813364,0.9956935,0.00003007286,0.002367367,0.00009173425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978117,0.0001693208,0.0001491127,0.001018891,0.0002578512,0.0002842831,0.0000149352,0.00001835329,0.0002755351],"genre_scores_gemma":[0.9975404,0.00001583756,0.00002869774,0.00006542225,0.0002473592,0.00002451061,0.00000504889,0.00002115575,0.002051605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002662533,"threshold_uncertainty_score":0.3097762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007275039886790923,"score_gpt":0.2137734995778,"score_spread":0.2064984596910091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}