{"id":"W2495036841","doi":"10.1111/jcmm.12903","title":"Activation of liver X receptor attenuates lysophosphatidylcholine‐induced <scp>IL</scp>‐8 expression in endothelial cells <i>via</i> the <scp>NF</scp>‐κB pathway and <scp>SUMO</scp>ylation","year":2016,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Canadian Institutes of Health Research; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"SUMO protein; Liver X receptor; Agonist; Transrepression; Gene knockdown; Chemistry; IκBα; Cell biology; Proinflammatory cytokine; Molecular biology; Signal transduction; Biology; Receptor; NF-κB; Nuclear receptor; Inflammation; Transcription factor; Biochemistry; Ubiquitin; Immunology; Transactivation; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001468993,0.0004259514,0.0009853119,0.00043765,0.0001004179,0.00002696767,0.0002155553,0.0003041323,0.00001315688],"category_scores_gemma":[0.001895087,0.0002361944,0.0002008158,0.0003437051,0.0002677423,0.000326529,0.00009282267,0.0005820263,0.000005918412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005520117,"about_ca_system_score_gemma":0.0001300868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004321585,"about_ca_topic_score_gemma":0.000002551914,"domain_scores_codex":[0.9966077,0.0003354495,0.001190403,0.0004054219,0.00101603,0.0004450163],"domain_scores_gemma":[0.9965091,0.001134572,0.001106089,0.0004024744,0.0004488666,0.0003989003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005210873,0.0001821507,0.00148509,0.0001582124,0.00009158134,0.00008648421,0.002830357,0.000004349295,0.9821755,0.00004822045,0.001155619,0.01173032],"study_design_scores_gemma":[0.007624979,0.0007792371,0.007565282,0.00158295,0.0002795918,0.0001458016,0.0008926372,0.0000825383,0.944475,0.0001648324,0.03636155,0.00004560384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833248,0.008317134,0.005906763,0.0008791342,0.0006453039,0.0005762762,0.00001667847,0.00001695726,0.0003169434],"genre_scores_gemma":[0.9920101,0.004613703,0.0004904501,0.0008214515,0.001320829,0.00001092916,0.00002000564,0.00006371734,0.0006488282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03770051,"threshold_uncertainty_score":0.9631726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150647434624778,"score_gpt":0.2250014861999349,"score_spread":0.2134950118536871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}