{"id":"W2495036841","doi":"10.1111/jcmm.12903","title":"Activation of liver X receptor attenuates lysophosphatidylcholine‐induced <scp>IL</scp>‐8 expression in endothelial cells <i>via</i> the <scp>NF</scp>‐κB pathway and <scp>SUMO</scp>ylation","year":2016,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Canadian Institutes of Health Research; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"SUMO protein; Liver X receptor; Agonist; Transrepression; Gene knockdown; Chemistry; IκBα; Cell biology; Proinflammatory cytokine; Molecular biology; Signal transduction; Biology; Receptor; NF-κB; Nuclear receptor; Inflammation; Transcription factor; Biochemistry; Ubiquitin; Immunology; Transactivation; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163927,0.0004298945,0.0003811442,0.0001488984,0.0001414742,0.000273313,0.0001811814,0.0002851945,0.001503498],"category_scores_gemma":[0.000122617,0.0001653813,0.0003744793,0.0001455734,0.000244047,0.0001948438,0.0001790874,0.0008271714,0.0005154843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001882522,"about_ca_system_score_gemma":0.0003415431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008100414,"about_ca_topic_score_gemma":0.0008891755,"domain_scores_codex":[0.9998345,0.00003586605,0.00002589045,0.00001884749,0.00002628775,0.00005849193],"domain_scores_gemma":[0.999916,0.000008567153,0.00002389977,0.00001259452,0.00001037078,0.00002857031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001336775,0.0002558245,0.0001677435,0.0001026637,0.0000175506,0.00008345445,0.00002734951,0.00008058332,0.9960169,0.00008590263,0.0001594426,0.001665749],"study_design_scores_gemma":[0.0001384575,0.001780192,0.003464291,0.0000131378,0.00003713071,0.0001658999,0.00005904101,0.001222714,0.9908863,0.00004534704,0.002180971,0.000006604726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953125,0.001778294,0.001016965,0.0001666955,0.00008667014,0.00002986839,0.0002534348,0.0001021149,0.001253486],"genre_scores_gemma":[0.9939971,0.001368762,0.0007458724,0.0001133765,0.00002567204,0.00006856828,0.0005907296,0.00001554455,0.003074271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503498,"threshold_uncertainty_score":0.005029678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150647434624778,"score_gpt":0.2250014861999349,"score_spread":0.2134950118536871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}