{"id":"W2495484125","doi":"10.1021/bk-2006-0923.ch005","title":"Synthesis and Evaluation of Hydrophobically-Modified Polysaccharides as Oral Delivery Vehicles for Poorly Water-Soluble Drugs","year":2006,"lang":"en","type":"book-chapter","venue":"ACS symposium series","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Micelle; Bioavailability; Polysaccharide; Chemistry; Dextran; Aqueous solution; Drug delivery; Copolymer; Water soluble; Drug carrier; Chromatography; Organic chemistry; Polymer; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002546942,0.0003381004,0.0002067453,0.0001576042,0.0001077044,0.000242221,0.0001516572,0.0002464891,0.0004938593],"category_scores_gemma":[0.0002203125,0.0001338272,0.0001639903,0.0001459629,0.0001796252,0.0003278005,0.0001609175,0.0002435937,0.0002039735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002507455,"about_ca_system_score_gemma":0.000219617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003939701,"about_ca_topic_score_gemma":0.0004593418,"domain_scores_codex":[0.9999188,0.00002194653,0.000007076559,0.00001212935,0.00002908001,0.00001100873],"domain_scores_gemma":[0.9998991,0.0000187286,0.00003561195,0.000008563766,0.00001915112,0.0000186682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004871761,0.00002432625,0.00003541403,0.00005358579,0.000002814367,0.00003327173,0.000009107348,0.0001622552,0.9969816,0.00007420427,0.00001057528,0.002564108],"study_design_scores_gemma":[0.00001779931,0.0005251073,0.000479803,0.000006920069,0.00001530096,0.00009189842,0.000007409488,0.000567683,0.996333,0.00002453107,0.001926253,0.000004257603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772916,0.009772342,0.01094523,0.0001011596,0.00004494955,0.0001571109,0.0001769663,0.00006148799,0.001449041],"genre_scores_gemma":[0.9612387,0.008148712,0.02667352,0.00005537232,0.00003442057,0.0001145983,0.0003822239,0.00003872696,0.003313775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004938593,"threshold_uncertainty_score":0.001819253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06582575655909573,"score_gpt":0.3541751047442652,"score_spread":0.2883493481851694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}