{"id":"W2495494314","doi":"10.1039/c6md00328a","title":"Design, synthesis and evaluation of cytotoxic properties of bisamino glucosylated antitumor ether lipids against cancer cells and cancer stem cells","year":2016,"lang":"en","type":"article","venue":"MedChemComm","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council; Canadian Cancer Society; University of Manitoba","keywords":"Cancer cell; Ether; Cancer; Cancer stem cell; Chemistry; Amphiphile; Cytotoxic T cell; Apoptosis; Biochemistry; Cytotoxicity; Cancer research; Biology; Combinatorial chemistry; Stereochemistry; In vitro; Organic chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000542345,0.000179082,0.0003071852,0.00005500385,0.00003799635,0.00000877534,0.0001141423,0.0001396211,0.00003840405],"category_scores_gemma":[0.00004013818,0.0001221688,0.00004922566,0.00007536945,0.0002531713,0.000009291292,0.00007421214,0.00004280643,8.245844e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002574716,"about_ca_system_score_gemma":0.0001987512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001482126,"about_ca_topic_score_gemma":0.0000679299,"domain_scores_codex":[0.9988082,0.0001853008,0.0002719726,0.0003041389,0.0002352054,0.0001951659],"domain_scores_gemma":[0.9991435,0.00002929406,0.0001860859,0.0002728141,0.0002980107,0.00007024886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112447,0.00003722917,0.0003823706,0.0001180103,0.00009461101,8.463599e-8,0.0001563322,0.00004026493,0.9234513,0.000001471827,0.0003753379,0.07523055],"study_design_scores_gemma":[0.0008350426,0.00005470054,0.0005409055,0.0002350362,0.0001641918,8.687491e-7,0.00005808825,0.0001659484,0.9933103,0.000006468328,0.004452525,0.0001759499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706886,0.02814816,0.0001665965,0.00008076968,0.0003846805,0.0004000247,0.00007482366,0.000006882033,0.00004945811],"genre_scores_gemma":[0.9824256,0.01663547,0.0001630991,0.0000501815,0.0002657672,0.0001419188,0.000001550656,0.00002753157,0.0002888843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07505461,"threshold_uncertainty_score":0.4981897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816353738498118,"score_gpt":0.2626581414273483,"score_spread":0.2244946040423671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}