{"id":"W2495494314","doi":"10.1039/c6md00328a","title":"Design, synthesis and evaluation of cytotoxic properties of bisamino glucosylated antitumor ether lipids against cancer cells and cancer stem cells","year":2016,"lang":"en","type":"article","venue":"MedChemComm","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council; Canadian Cancer Society; University of Manitoba","keywords":"Cancer cell; Ether; Cancer; Cancer stem cell; Chemistry; Amphiphile; Cytotoxic T cell; Apoptosis; Biochemistry; Cytotoxicity; Cancer research; Biology; Combinatorial chemistry; Stereochemistry; In vitro; Organic chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000198025,0.0002344213,0.0001120503,0.0002567684,0.0001354181,0.0002196292,0.0001866846,0.0002060451,0.0007233229],"category_scores_gemma":[0.0001654419,0.0001011851,0.0001743155,0.0001908985,0.0001118429,0.0002146318,0.0001737261,0.0002942998,0.0002706641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002300799,"about_ca_system_score_gemma":0.0002587084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003632308,"about_ca_topic_score_gemma":0.0005067021,"domain_scores_codex":[0.9999322,0.00001140227,0.000008535446,0.00001086455,0.00002195085,0.00001498572],"domain_scores_gemma":[0.999917,0.000008374317,0.000025658,0.000008486252,0.00002277305,0.00001768861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000132151,0.00004975633,0.0001124233,0.00004185694,0.000003759899,0.0000512464,0.00001826069,0.0005848411,0.994504,0.0003052686,0.00003180581,0.004164557],"study_design_scores_gemma":[0.00001504417,0.0003095532,0.0001606865,0.000002210623,0.000007715531,0.00002540853,0.000006638776,0.0003010547,0.9975538,0.00002148225,0.001593688,0.000002702964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889737,0.0009499602,0.006845176,0.00006661497,0.00002190348,0.0001814702,0.000288807,0.00004691725,0.002625523],"genre_scores_gemma":[0.9877665,0.001173437,0.008010887,0.00003611588,0.000006251657,0.0001075688,0.0003996351,0.00002064542,0.002479054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007233229,"threshold_uncertainty_score":0.00241977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816353738498118,"score_gpt":0.2626581414273483,"score_spread":0.2244946040423671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}