{"id":"W2495582206","doi":"10.1016/j.cell.2016.06.056","title":"NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":381,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute on Aging; National Cancer Institute; KWF Kankerbestrijding; Canadian Cancer Society Research Institute; National Institutes of Health; Sociedad Española de Oncología Médica; Vetenskapsrådet; Human Frontier Science Program; Starr Foundation; Memorial Sloan-Kettering Cancer Center; Canadian Institutes of Health Research; Damon Runyon Cancer Research Foundation; U.S. Department of Defense; Pancreatic Cancer UK; Stand Up To Cancer","keywords":"Biology; Translation (biology); Pancreatic cancer; Messenger RNA; Cancer research; Cancer; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001625785,0.0001732429,0.0002532445,0.0002345706,0.0001967733,0.000320055,0.000109767,0.0001949484,0.002071306],"category_scores_gemma":[0.00008141647,0.0001143034,0.0002001726,0.0002185719,0.0001674666,0.0002582055,0.0001404031,0.0003734831,0.0002850436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795572,"about_ca_system_score_gemma":0.0001674887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005383226,"about_ca_topic_score_gemma":0.001202247,"domain_scores_codex":[0.999931,0.00001462181,0.000005959893,0.00001559706,0.00001446023,0.0000183657],"domain_scores_gemma":[0.9999541,0.000007019868,0.000009392295,0.00000708329,0.000007827241,0.00001455359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004748459,0.00003346687,0.0003329946,0.00003781556,0.000007100449,0.00004376052,0.00001200537,0.00003292399,0.9973143,0.0001182863,0.0001080502,0.001484385],"study_design_scores_gemma":[0.00003795319,0.0003475505,0.01064272,0.000007319253,0.00003300797,0.0002105849,0.0000744536,0.0004915618,0.9837874,0.0001503782,0.004212038,0.000005181661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915576,0.004032431,0.001521714,0.0004428492,0.00005395911,0.00001104608,0.0004924993,0.0001168391,0.001771143],"genre_scores_gemma":[0.9942033,0.001455074,0.0007007932,0.00007569754,0.00001894456,0.00001230447,0.000390316,0.00001971525,0.003123858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002071306,"threshold_uncertainty_score":0.006929159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00984459930100637,"score_gpt":0.2302657547443793,"score_spread":0.2204211554433729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}