{"id":"W2495582206","doi":"10.1016/j.cell.2016.06.056","title":"NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":381,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute on Aging; National Cancer Institute; KWF Kankerbestrijding; Canadian Cancer Society Research Institute; National Institutes of Health; Sociedad Española de Oncología Médica; Vetenskapsrådet; Human Frontier Science Program; Starr Foundation; Memorial Sloan-Kettering Cancer Center; Canadian Institutes of Health Research; Damon Runyon Cancer Research Foundation; U.S. Department of Defense; Pancreatic Cancer UK; Stand Up To Cancer","keywords":"Biology; Translation (biology); Pancreatic cancer; Messenger RNA; Cancer research; Cancer; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000665475,0.0001144498,0.0001160009,0.00001604929,0.0000236423,0.000007750931,0.0001045917,0.0000593292,0.00002996448],"category_scores_gemma":[0.00003526789,0.00008732743,0.00004003794,0.00003744265,0.00005000515,0.000004149304,0.0000219582,0.00004217693,0.00000723307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002319024,"about_ca_system_score_gemma":0.00002844037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004736677,"about_ca_topic_score_gemma":0.00004934448,"domain_scores_codex":[0.9992549,0.00002748606,0.0001640902,0.0002810227,0.00005331299,0.0002191938],"domain_scores_gemma":[0.9996759,0.00001630913,0.00006900021,0.000161701,0.00003264696,0.00004448047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000267762,0.00002955589,0.008581785,0.00002459157,0.000005761027,7.433858e-7,0.00005509388,0.00001047439,0.9877132,0.000001954833,0.0005855224,0.002964609],"study_design_scores_gemma":[0.0006569094,0.00004035846,0.002579952,0.00005839029,0.000005608554,7.514553e-7,0.0000268842,0.0000982381,0.9931414,0.0001791523,0.003062873,0.0001494833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955335,0.001317942,0.00147238,0.000186733,0.00005289832,0.0001711281,0.0000534734,0.000006808883,0.001205095],"genre_scores_gemma":[0.9979838,0.0002136885,0.0006105032,0.00009206159,0.00009991859,0.00004029842,0.00003307048,0.00001771644,0.0009089342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006001832,"threshold_uncertainty_score":0.3561109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00984459930100637,"score_gpt":0.2302657547443793,"score_spread":0.2204211554433729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}