{"id":"W2495757385","doi":"10.1016/j.expneurol.2016.07.019","title":"Activation of CRHR1 receptors regulates social and depressive-like behaviors and expression of BDNF and TrkB in mesocorticolimbic regions following global cerebral ischemia","year":2016,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Tropomyosin receptor kinase B; Conditioned place preference; Nucleus accumbens; Neurotrophic factors; Endocrinology; Internal medicine; Anhedonia; Ventral tegmental area; Behavioural despair test; Hippocampus; Psychology; Brain-derived neurotrophic factor; Prefrontal cortex; Ischemia; Neuroscience; Elevated plus maze; Receptor; Medicine; Antidepressant; Psychiatry; Anxiety; Dopamine; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587856,0.0004906944,0.0006441348,0.0003066907,0.0003131656,0.0003979911,0.0002890997,0.000386277,0.001340112],"category_scores_gemma":[0.0002304392,0.0002894756,0.0004282009,0.0001731569,0.0007600446,0.0004361047,0.0002074896,0.001271713,0.0002285237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007451089,"about_ca_system_score_gemma":0.0004934373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002633832,"about_ca_topic_score_gemma":0.005954796,"domain_scores_codex":[0.9997724,0.00001738268,0.00001124391,0.00003696036,0.00002030579,0.0001418449],"domain_scores_gemma":[0.9998254,0.00001399625,0.00006014782,0.00001814251,0.00001550026,0.00006678456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006746385,0.0002346712,0.0006374138,0.00007665724,0.00003762768,0.0002722166,0.0001072306,0.0001385043,0.9888431,0.0002895943,0.000190438,0.002426133],"study_design_scores_gemma":[0.0004603443,0.002675514,0.08627873,0.00003573254,0.0002357578,0.000587515,0.0006763078,0.001794406,0.9053305,0.0005241542,0.001352577,0.00004857474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978741,0.0007436575,0.0004614826,0.0001357442,0.00003994125,0.00001498111,0.0001632774,0.00002536238,0.0005413106],"genre_scores_gemma":[0.9969337,0.000596321,0.0004128068,0.00006270257,0.00002150607,0.00005499623,0.0001943863,0.00001303021,0.001710545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002633832,"threshold_uncertainty_score":0.005406141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062381406158246,"score_gpt":0.2965184208506214,"score_spread":0.2758946067890389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}