{"id":"W2496018230","doi":"10.1016/j.cbi.2016.07.028","title":"Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway","year":2016,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Flavonoids in Medical Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Science Foundation of Zhejiang Province; Zhejiang Traditional Chinese Medicine Administration","keywords":"Luteolin; MAPK/ERK pathway; Protein kinase B; Apoptosis; A549 cell; Cancer research; Kinase; Signal transduction; Chemistry; PI3K/AKT/mTOR pathway; Cell biology; Biology; Biochemistry; Flavonoid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004543617,0.0002357011,0.000416181,0.00008077845,0.0001472563,0.00002195884,0.0001630021,0.000229733,0.0001925187],"category_scores_gemma":[0.003735563,0.0001096095,0.0001403551,0.0002208834,0.0003545844,0.0001496626,0.00009769538,0.0005845336,0.00003700497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001801525,"about_ca_system_score_gemma":0.00004923185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002017672,"about_ca_topic_score_gemma":0.000001178838,"domain_scores_codex":[0.9982095,0.0002629755,0.0003896816,0.0004456931,0.0003498543,0.000342237],"domain_scores_gemma":[0.9937451,0.005456714,0.0001641329,0.0003535616,0.0001418218,0.000138611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003270495,0.0001559782,0.003042017,0.0001838733,0.00006810499,0.000008150096,0.0002202725,0.000003087815,0.9879343,0.0001625848,0.001177627,0.006716992],"study_design_scores_gemma":[0.000878659,0.0008287432,0.004659533,0.001065293,0.0000562897,0.00001575621,0.00006223039,0.0002237365,0.9913329,0.0002492912,0.0005011446,0.0001264569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936177,0.0001464087,0.001585282,0.002510304,0.0002420585,0.001044023,0.000007353491,0.0000665486,0.0007803387],"genre_scores_gemma":[0.9983789,0.0001170577,0.0002820149,0.0003606957,0.0003233936,0.0001650987,0.00002477255,0.00002018238,0.0003279183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006590535,"threshold_uncertainty_score":0.4472088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0348344965243199,"score_gpt":0.3338055388775008,"score_spread":0.2989710423531808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}