{"id":"W2496244196","doi":"10.1002/jcph.691","title":"Impact of Transporter Polymorphisms on Drug Development: Is It Clinically Significant?","year":2016,"lang":"en","type":"review","venue":"The Journal of Clinical Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Transporter; Drug; Drug development; Pharmacology; Efflux; Computational biology; ATP-binding cassette transporter; Personalized medicine; Drug discovery; Biology; Medicine; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.007111706,0.000623834,0.005948149,0.0003163113,0.00007157176,0.000004957654,0.0009725498,0.0006987499,0.004595172],"category_scores_gemma":[0.0001415626,0.0002627415,0.004466683,0.0002538373,0.0005942247,0.00005850627,0.00003122775,0.002430617,0.0001894306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001164094,"about_ca_system_score_gemma":0.003847952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002134568,"about_ca_topic_score_gemma":6.398492e-7,"domain_scores_codex":[0.9896331,0.001007947,0.007700154,0.0003627139,0.0007656051,0.0005304411],"domain_scores_gemma":[0.9894825,0.003868576,0.005185287,0.0004578716,0.0004094032,0.0005963735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00990945,0.002361274,0.0004177695,0.003122573,0.008548658,0.0006853417,0.0004288857,9.769349e-7,0.0001185871,0.00001062746,0.0522153,0.9221805],"study_design_scores_gemma":[0.005429104,0.003133178,0.001207362,0.01439178,0.009781802,0.0001913443,0.00001515913,5.045369e-7,0.0001262998,0.00005823432,0.9653057,0.0003595689],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01122409,0.9762943,0.0003042435,0.003523046,0.005520788,0.001470544,0.000136119,0.000022609,0.0015043],"genre_scores_gemma":[0.006294081,0.9864528,0.000238731,0.002027906,0.002286617,0.000007227043,0.0000111449,0.00008932733,0.002592164],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.921821,"threshold_uncertainty_score":0.9999825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1425352898254683,"score_gpt":0.5002124890627286,"score_spread":0.3576771992372604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}