{"id":"W2496913237","doi":"10.1371/journal.pone.0158801","title":"Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers","year":2016,"lang":"en","type":"review","venue":"PLoS ONE","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Health and Medical Research Council; Medical Research Council; lékařská fakulta Univerzity Karlovy; University of California, San Francisco; National Institutes of Health; Ministero dello Sviluppo Economico; National Cancer Institute; Hospices Civils de Lyon; Institut Gustave-Roussy; Sahlgrenska Universitetssjukhuset; Università degli Studi di Firenze; Jewish General Hospital; Lunds Universitet; Uppsala Universitet; Cancer Australia; Linköpings Universitet; Cancer Research UK; University of Chicago; McGill University; Univerzita Karlova v Praze; National Breast Cancer Foundation; Umeå Universitet; University of Pennsylvania; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Francis Crick Institute; Centre Léon Bérard; Breast Cancer Research Foundation; Susan G. Komen for the Cure","keywords":"Ovarian cancer; Mutation; Biology; Genetics; Cancer; Scale (ratio); Computational biology; Cancer research; Geography; Cartography; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008769195,0.000452024,0.000429358,0.000850154,0.0004024158,0.0005624941,0.0004271342,0.0006018672,0.002898369],"category_scores_gemma":[0.003008375,0.0003492957,0.001021407,0.00076043,0.0003211817,0.0001485767,0.0005469681,0.0005363961,0.0003231523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001583562,"about_ca_system_score_gemma":0.0002019994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003800262,"about_ca_topic_score_gemma":0.004391849,"domain_scores_codex":[0.9993827,0.0001407966,0.00003487594,0.0002905343,0.00007649039,0.00007456786],"domain_scores_gemma":[0.9987921,0.0005233173,0.0003326976,0.0002004164,0.00005353301,0.00009791934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002060316,0.0001720202,0.9220112,0.00007156633,0.001136813,0.00311486,0.0003744527,0.001456854,0.05407163,0.0004031928,0.0005592757,0.01456792],"study_design_scores_gemma":[0.000101901,0.0001960691,0.9932963,0.00001286264,0.000320014,0.001577444,0.00005807786,0.001100382,0.002092171,0.0003366612,0.0008962941,0.00001194574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9971311,0.0003359378,0.00135505,0.00007146931,0.00001043963,0.00002365125,0.0005915831,0.00003087442,0.0004498062],"genre_scores_gemma":[0.9983116,0.0001082869,0.0007089757,0.00004760595,0.00001098513,0.0000169984,0.0004617343,0.00001159645,0.0003223228],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003800262,"threshold_uncertainty_score":0.009696007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04402537247121266,"score_gpt":0.293049774321305,"score_spread":0.2490244018500923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}