{"id":"W2496973033","doi":"10.1158/1538-7445.am2016-ct146","title":"Abstract CT146: A phase IB study of the combination of AZD6244 hydrogen sulfate (selumetinib) and cyclosporin A (CsA) in patients with advanced solid tumors with an expansion cohort in metastatic colorectal cancer (mCRC)","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Selumetinib; Wnt signaling pathway; Medicine; KRAS; MEK inhibitor; Colorectal cancer; Cancer research; Cancer; Oncology; MAPK/ERK pathway; Internal medicine; Pharmacology; Kinase; Biology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007759746,0.001104539,0.00128978,0.0003709233,0.0003857546,0.000847575,0.000785322,0.0008600467,0.003526191],"category_scores_gemma":[0.0004559385,0.0003058515,0.000858276,0.0004099887,0.0005374423,0.0005208185,0.0002984759,0.002676234,0.0009198113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007957618,"about_ca_system_score_gemma":0.001319203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242297,"about_ca_topic_score_gemma":0.004052781,"domain_scores_codex":[0.9997751,0.00008970185,0.00001621693,0.00003969403,0.00003597498,0.00004326799],"domain_scores_gemma":[0.9995871,0.00003907389,0.00005923407,0.00002923509,0.00003247471,0.0002528483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4427095,0.08380087,0.01811275,0.001374034,0.002004858,0.00121613,0.0005449645,0.006392675,0.2698878,0.0006453606,0.009040504,0.1642705],"study_design_scores_gemma":[0.2929233,0.6397511,0.03054833,0.00007060089,0.0006986962,0.001509152,0.0001221462,0.002871922,0.02517961,0.0001696136,0.006107382,0.00004822696],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933566,0.001458613,0.0003789658,0.0003648789,0.00006836966,0.001214204,0.001026496,0.00009344686,0.002038326],"genre_scores_gemma":[0.9912934,0.001083326,0.001225459,0.0004618207,0.00007251833,0.0008186862,0.002392,0.00002106744,0.002631724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003526191,"threshold_uncertainty_score":0.01179624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852968317643866,"score_gpt":0.3465377941984861,"score_spread":0.3280081110220475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}