{"id":"W2498089677","doi":"10.2147/blctt.s84157","title":"Waldenström macroglobulinemia: biology, genetics, and therapy","year":2016,"lang":"en","type":"review","venue":"Blood and Lymphatic Cancer Targets and Therapy","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Stephen's University","funders":"","keywords":"Ibrutinib; Waldenstrom macroglobulinemia; Bruton's tyrosine kinase; Medicine; Lymphoplasmacytic Lymphoma; Rituximab; Oncology; Lymphoma; Macroglobulinemia; CXCR4; Internal medicine; Germline mutation; Cancer research; Immunology; Leukemia; Chronic lymphocytic leukemia; Biology; Mutation; Tyrosine kinase; Genetics; Multiple myeloma; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003866974,0.0004926529,0.0003898855,0.000579173,0.0003139733,0.0007876029,0.0003108099,0.0007525657,0.001826779],"category_scores_gemma":[0.0005633337,0.00008518283,0.0001737541,0.0004299199,0.0004303103,0.0003848634,0.00049788,0.001128823,0.001047985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009754986,"about_ca_system_score_gemma":0.0005845772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006169857,"about_ca_topic_score_gemma":0.001293591,"domain_scores_codex":[0.9998493,0.00003308716,0.00001192452,0.00001597403,0.00005961837,0.00003002464],"domain_scores_gemma":[0.9998751,0.0000210931,0.00002924237,0.000004930609,0.00002268997,0.00004700808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003566974,0.0002904184,0.009950854,0.0006205675,0.00007114613,0.006830821,0.0001172114,0.000808773,0.009205976,0.01233291,0.09162208,0.8677925],"study_design_scores_gemma":[0.000341992,0.001137943,0.01828524,0.001344967,0.0001104291,0.03893325,0.0001273825,0.002125078,0.007606432,0.01111069,0.9188139,0.00006274495],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07993923,0.7794657,0.003539378,0.05136369,0.003260012,0.0001148306,0.0003310071,0.0003947486,0.0815914],"genre_scores_gemma":[0.6429956,0.2912787,0.007797085,0.01553081,0.007328317,0.0002034886,0.0007500161,0.00005550028,0.03406047],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001826779,"threshold_uncertainty_score":0.007077813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06055768449692186,"score_gpt":0.3826594748749941,"score_spread":0.3221017903780722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}