{"id":"W2498363247","doi":"10.1158/1538-7445.am2016-4411","title":"Abstract 4411: Cadherin engagement induces a dramatic increase in tyr-705 phosphorylation of the signal transducer and activator of transcription-3 (Stat3α) but not the dominant-negative isoform Stat3β","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Queen's University","funders":"","keywords":"STAT3; STAT protein; Biology; Phosphorylation; Cancer research; Cell biology; Transcription factor; Tyrosine phosphorylation; SH2 domain; Autocrine signalling; Molecular biology; Receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006600573,0.0003636847,0.000153407,0.0001700727,0.0001274052,0.0002301209,0.00009267945,0.0001904137,0.004695624],"category_scores_gemma":[0.00004649049,0.0001162769,0.0002470543,0.0001418806,0.0001371901,0.0001048305,0.000153516,0.0005411841,0.0007939583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751823,"about_ca_system_score_gemma":0.0001589622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005541777,"about_ca_topic_score_gemma":0.0008899804,"domain_scores_codex":[0.999819,0.00002140797,0.00001233979,0.00002474038,0.00004532094,0.00007721971],"domain_scores_gemma":[0.9999396,0.000007846185,0.0000121012,0.000005674077,0.000005172912,0.0000295929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001267951,0.0000352136,0.00009159112,0.000024836,0.000004380392,0.00004759277,0.000006248394,0.00001257252,0.9991666,0.0000464422,0.00007816539,0.000359466],"study_design_scores_gemma":[0.00003218207,0.0004650947,0.009945262,0.000008175333,0.00001476707,0.0003969809,0.00003185576,0.0005207303,0.9848136,0.00004094322,0.003726892,0.000003479692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942294,0.001281907,0.0008078919,0.0001318385,0.0000798552,0.00002129243,0.0007749038,0.00006195202,0.002610791],"genre_scores_gemma":[0.9896573,0.000819147,0.000722371,0.0001731133,0.00002252148,0.00003921671,0.002313585,0.00001815742,0.006234491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004695624,"threshold_uncertainty_score":0.01570845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08769687765132472,"score_gpt":0.3732763646211735,"score_spread":0.2855794869698488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}