{"id":"W2498901811","doi":"10.1016/j.cmet.2016.07.018","title":"Empagliflozin’s Fuel Hypothesis: Not so Soon","year":2016,"lang":"en","type":"letter","venue":"Cell Metabolism","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; University of Alberta","funders":"","keywords":"Empagliflozin; Computational biology; Aeronautics; Medicine; Biology; Engineering; Diabetes mellitus; Endocrinology; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001913349,0.0007083109,0.001215108,0.0005764569,0.00008587391,0.0001004667,0.0003467478,0.0007289752,0.001617973],"category_scores_gemma":[0.00003894012,0.0004832051,0.0005806382,0.0001742362,0.0001339256,0.000102129,0.0001558964,0.0007700876,0.005952546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000103047,"about_ca_system_score_gemma":0.0001288088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001706375,"about_ca_topic_score_gemma":0.000001133808,"domain_scores_codex":[0.9970077,0.00008712049,0.0004623762,0.000817258,0.0006993414,0.0009262012],"domain_scores_gemma":[0.9981148,0.000118278,0.0002645583,0.001227009,0.00009704628,0.0001782636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002575326,0.00009243471,0.00004950719,0.000668329,0.0005819965,0.0005539282,0.00008360946,2.842497e-8,0.0005964891,0.00007729229,0.9715862,0.02568438],"study_design_scores_gemma":[0.002371087,0.00007114359,0.0005766003,0.0002054516,0.003218001,0.000004611665,0.00001415318,9.314743e-7,0.00378941,0.00042043,0.9888116,0.0005166352],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002923625,0.01521543,0.00002823161,0.8073407,0.004058624,0.001771799,0.0001290146,0.0004493411,0.1680832],"genre_scores_gemma":[0.001464887,0.001988414,0.0006992028,0.6425296,0.01335253,0.0002253562,0.0001961735,0.0001963154,0.3393475],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1712643,"threshold_uncertainty_score":0.9997619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02296589570410121,"score_gpt":0.2250640468878559,"score_spread":0.2020981511837547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}