{"id":"W2499298945","doi":"10.1089/scd.2016.0103","title":"Small-Molecule Induction of Canine Embryonic Stem Cells Toward Naïve Pluripotency","year":2016,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Induced pluripotent stem cell; Embryonic stem cell; Rex1; Epiblast; Cell biology; Leukemia inhibitory factor; Stem cell; Molecular biology; Genetics; Embryo; Embryogenesis; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003405245,0.0002672325,0.000276523,0.0001020349,0.00009743312,0.00002337473,0.0002456529,0.0001991478,0.00003893132],"category_scores_gemma":[0.000003338631,0.0001967594,0.00006823359,0.000113988,0.0001072309,0.000007950644,0.0003220598,0.000089426,0.00005501206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006960958,"about_ca_system_score_gemma":0.0003891702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003244419,"about_ca_topic_score_gemma":0.00003210244,"domain_scores_codex":[0.9980993,0.00008732925,0.0004257677,0.0005927994,0.0003231723,0.0004716708],"domain_scores_gemma":[0.9990914,0.0000162293,0.0001657014,0.0003437245,0.0001781555,0.0002047435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007397241,0.00006253976,0.0002755053,0.0001484655,0.00008535876,0.000009077905,0.0001537111,0.000007528607,0.963815,0.00001295642,0.0006911473,0.0346647],"study_design_scores_gemma":[0.0008408554,0.0002282237,0.0008188382,0.0000822648,0.00001049036,0.00001355422,0.0001882955,0.000005324046,0.9754261,0.000004443023,0.02209219,0.0002894306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947797,0.001342668,0.00220964,0.0001708729,0.0002946549,0.0003951902,0.00002832421,0.00001737027,0.0007615467],"genre_scores_gemma":[0.985774,0.001239354,0.0009382402,0.00004709944,0.00007878301,0.00003806514,0.00001412117,0.00003777521,0.01183256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03437527,"threshold_uncertainty_score":0.8023617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02570796969577751,"score_gpt":0.2327757006843654,"score_spread":0.2070677309885879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}