{"id":"W2499298945","doi":"10.1089/scd.2016.0103","title":"Small-Molecule Induction of Canine Embryonic Stem Cells Toward Naïve Pluripotency","year":2016,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Induced pluripotent stem cell; Embryonic stem cell; Rex1; Epiblast; Cell biology; Leukemia inhibitory factor; Stem cell; Molecular biology; Genetics; Embryo; Embryogenesis; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001845725,0.0002775209,0.0001997806,0.0002236834,0.00008178117,0.0002118187,0.0001803336,0.0001500861,0.0006490731],"category_scores_gemma":[0.000110033,0.0001093829,0.0002252425,0.0001060567,0.0001587985,0.0001213813,0.000191668,0.0003697209,0.0001553881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001605948,"about_ca_system_score_gemma":0.0001566979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002457024,"about_ca_topic_score_gemma":0.0005812551,"domain_scores_codex":[0.9998879,0.00001510993,0.00001568113,0.00002491454,0.00003250209,0.00002376967],"domain_scores_gemma":[0.9999346,0.00001736645,0.00001754202,0.000008246077,0.000008107563,0.00001417027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003768303,0.00001426034,0.00008353205,0.00003478161,0.000002324268,0.00002279494,0.00001222934,0.00006234807,0.9987587,0.00008006986,0.0000265593,0.0008647043],"study_design_scores_gemma":[0.00001592619,0.0004013761,0.001256956,0.000004660529,0.00001163785,0.0001041018,0.00001291642,0.0004099185,0.9949744,0.00002724932,0.002778139,0.000002804456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913338,0.001353124,0.004901702,0.0000659307,0.00003843922,0.00007941446,0.000515096,0.0001277135,0.001584772],"genre_scores_gemma":[0.9878988,0.001349094,0.00716265,0.00007262576,0.00001672739,0.00009274697,0.00143978,0.00002735359,0.001940342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006490731,"threshold_uncertainty_score":0.002171338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02570796969577751,"score_gpt":0.2327757006843654,"score_spread":0.2070677309885879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}