{"id":"W2499374012","doi":"10.1016/j.ebiom.2016.07.022","title":"Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer","year":2016,"lang":"en","type":"review","venue":"EBioMedicine","topic":"Effects of Radiation Exposure","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"European Social Fund; Instituto de Salud Carlos III; Medical Research Council; National Institutes of Health; Xunta de Galicia; American Cancer Society; University of Cambridge; Cancer Research UK; Francis Crick Institute; Centre International de Recherche sur le Cancer; Royal Marsden NHS Foundation Trust; Icahn School of Medicine at Mount Sinai; Addenbrooke's Charitable Trust, Cambridge University Hospitals; Royal College of Radiologists; National Institute for Health and Care Research; National Cancer Institute; Seventh Framework Programme; University of Rochester; NIHR Cambridge Biomedical Research Centre; European Regional Development Fund; European Commission; U.S. Department of Defense","keywords":"Medicine; Prostate cancer; Odds ratio; Radiation therapy; Single-nucleotide polymorphism; Oncology; Internal medicine; Toxicity; Cancer; Biology; Genotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002102687,0.0004980004,0.008443226,0.00135931,0.00005221217,0.000007384731,0.0001995715,0.0002832398,0.0002460425],"category_scores_gemma":[0.001691678,0.0002986896,0.004067391,0.001383451,0.0001348268,0.00007146982,0.00003371917,0.0001544058,0.000001810478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007478318,"about_ca_system_score_gemma":0.0002802444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004450804,"about_ca_topic_score_gemma":0.0000311829,"domain_scores_codex":[0.9962785,0.0002804817,0.001741087,0.0005195834,0.000826936,0.000353448],"domain_scores_gemma":[0.9923396,0.003836389,0.002594326,0.0005680633,0.0005482258,0.000113421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001076694,0.00007783243,0.001533727,0.02395596,0.9026235,0.00001212743,0.0005871694,0.00002034948,0.0004582055,0.000001077399,0.00319574,0.06742661],"study_design_scores_gemma":[0.001463561,0.0005859674,0.001632927,0.002994759,0.7654345,0.000001164326,0.00003540304,0.00002127873,0.00004858816,0.00001626687,0.2274914,0.0002742406],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001297255,0.9929916,0.0002346222,0.00142426,0.0004649387,0.002851671,0.0006884462,0.00003216046,0.00001506876],"genre_scores_gemma":[0.0003064772,0.9910222,0.0006341636,0.0002479413,0.0002320492,0.0005862594,0.0002454469,0.00007498932,0.006650431],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2242956,"threshold_uncertainty_score":0.9999465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06422032203116668,"score_gpt":0.394426179029586,"score_spread":0.3302058569984194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}