{"id":"W2499392493","doi":"10.3390/vaccines4030027","title":"Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection","year":2016,"lang":"en","type":"article","venue":"Vaccines","topic":"Hepatitis C virus research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Medical Research Council; National Institute for Health and Care Research; Medical Research Council Canada; Wellcome Trust","keywords":"Immunogenicity; Virology; Immunology; T cell; Hepatitis C virus; CD8; Cytotoxic T cell; ELISPOT; Medicine; Biology; Immune system; Virus; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002726151,0.0002421539,0.0003272328,0.00009811895,0.00009235074,0.0002545048,0.0001022327,0.0003120019,0.0005469726],"category_scores_gemma":[0.0003678404,0.0001204435,0.0001349275,0.00007372508,0.0002523902,0.0001997766,0.0001368962,0.0006876126,0.0001813762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001716578,"about_ca_system_score_gemma":0.0002064305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002469028,"about_ca_topic_score_gemma":0.0002872359,"domain_scores_codex":[0.9998257,0.00005695965,0.00001797714,0.00002331861,0.00003316598,0.00004297072],"domain_scores_gemma":[0.9998522,0.00004763896,0.00002783987,0.00002602058,0.00001581247,0.00003037094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009338245,0.0003263727,0.002264932,0.00007583173,0.00002003717,0.0001465398,0.00006949346,0.0004890616,0.9863883,0.0002249791,0.00007571487,0.008984901],"study_design_scores_gemma":[0.001194367,0.03457608,0.0385878,0.00005692053,0.000187725,0.00387625,0.0001634047,0.008202179,0.9041892,0.000556696,0.008383318,0.00002604377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986664,0.0004696944,0.0005120192,0.00003085017,0.0000138744,0.00002118171,0.00001744277,0.00001644171,0.0002520247],"genre_scores_gemma":[0.9989337,0.0001770106,0.0004838434,0.0000476772,0.000016025,0.00001942258,0.00006281512,0.000004201085,0.0002552119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005469726,"threshold_uncertainty_score":0.001829743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00867945681648532,"score_gpt":0.2484279709251625,"score_spread":0.2397485141086772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}