{"id":"W2499392493","doi":"10.3390/vaccines4030027","title":"Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection","year":2016,"lang":"en","type":"article","venue":"Vaccines","topic":"Hepatitis C virus research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Medical Research Council; National Institute for Health and Care Research; Medical Research Council Canada; Wellcome Trust","keywords":"Immunogenicity; Virology; Immunology; T cell; Hepatitis C virus; CD8; Cytotoxic T cell; ELISPOT; Medicine; Biology; Immune system; Virus; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004873674,0.0002939227,0.0004375294,0.0003047652,0.0001992084,0.00002124576,0.0003203298,0.0001953484,0.000564452],"category_scores_gemma":[0.0004293234,0.0001736698,0.0002231111,0.000678937,0.00004721657,0.0002413655,0.0002656188,0.0002547606,0.0001740221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007045186,"about_ca_system_score_gemma":0.0004101752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001820562,"about_ca_topic_score_gemma":0.0003807653,"domain_scores_codex":[0.9975612,0.0003777252,0.0005169933,0.0004332775,0.0005671448,0.0005437239],"domain_scores_gemma":[0.9981233,0.0002983802,0.0002095901,0.0009398789,0.0002744497,0.0001543336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002104672,0.0001476091,0.1716794,0.0001984323,0.00003670108,0.000007094316,0.00005353568,0.000003291543,0.8196065,0.000001880548,0.005459828,0.0007010109],"study_design_scores_gemma":[0.004427935,0.000501498,0.3376868,0.0001965198,0.00005157896,0.00001084964,0.000007247994,0.00001840912,0.6386141,0.000007410073,0.01831534,0.0001622663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936495,0.00163567,0.00001282647,0.003051775,0.0003798825,0.0006893602,0.00005024648,0.0001046138,0.0004260771],"genre_scores_gemma":[0.9861377,0.001194901,0.00001858224,0.00007114515,0.0001952859,0.00003755832,0.000009601809,0.00006723212,0.01226798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1809924,"threshold_uncertainty_score":0.7082051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00867945681648532,"score_gpt":0.2484279709251625,"score_spread":0.2397485141086772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}