{"id":"W2499461011","doi":"10.1128/jvi.00936-16","title":"Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral Replication","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Rosetrees Trust; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Biology; Cytoplasm; Viral replication; Checkpoint Kinase 2; DNA damage; Apoptosis; Kinase; Virus; Virology; CHEK1; Cell biology; DNA replication; Molecular biology; Protein kinase A; Cell cycle; DNA; Cell cycle checkpoint; Protein-Serine-Threonine Kinases; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003756616,0.00007874477,0.0001594974,0.00001419017,0.0001657195,0.000007324038,0.0001062693,0.00009113441,0.00002333326],"category_scores_gemma":[0.0003098617,0.00002468724,0.00007560331,0.0001037197,0.0001336676,0.000100531,0.00004236518,0.00007551786,0.00000103761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000497619,"about_ca_system_score_gemma":0.000008883745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006353487,"about_ca_topic_score_gemma":0.00001572728,"domain_scores_codex":[0.9992821,0.00008224698,0.000256442,0.0001458672,0.0001191601,0.0001142357],"domain_scores_gemma":[0.9990058,0.0001867064,0.0005947459,0.00006069367,0.0001273221,0.00002471682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003029442,0.00007250372,0.001054659,0.000004309258,0.00001404561,2.474381e-8,0.00004327572,0.000003445738,0.9731579,0.000076264,0.0004021752,0.02486845],"study_design_scores_gemma":[0.0002935616,0.0009035155,0.1976517,0.00002374143,0.00002053511,0.000006006066,0.00002075457,0.00006385806,0.7990747,0.0004880851,0.001396578,0.00005693095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940033,0.00005692132,0.0004410255,0.005069928,0.00005126407,0.0003098742,0.00002361586,0.000005978659,0.00003810809],"genre_scores_gemma":[0.9996242,0.00002578384,0.00007499703,0.00009095797,0.00008729387,0.00001549458,7.555935e-7,9.866407e-7,0.00007954372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1965971,"threshold_uncertainty_score":0.1274597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817692678306491,"score_gpt":0.2439551646522731,"score_spread":0.2257782378692082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}