{"id":"W2499461011","doi":"10.1128/jvi.00936-16","title":"Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral Replication","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Rosetrees Trust; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Biology; Cytoplasm; Viral replication; Checkpoint Kinase 2; DNA damage; Apoptosis; Kinase; Virus; Virology; CHEK1; Cell biology; DNA replication; Molecular biology; Protein kinase A; Cell cycle; DNA; Cell cycle checkpoint; Protein-Serine-Threonine Kinases; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007508643,0.0004128274,0.0001565733,0.0001276364,0.00021373,0.0002818655,0.0002033746,0.0002712666,0.00133905],"category_scores_gemma":[0.000125345,0.0001169071,0.0001972766,0.00007851617,0.000240731,0.0001859818,0.0002043003,0.0004073713,0.0006562784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000502708,"about_ca_system_score_gemma":0.0002204922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005862989,"about_ca_topic_score_gemma":0.0009161439,"domain_scores_codex":[0.9998845,0.00001535014,0.00001233774,0.00002696434,0.0000265464,0.00003423467],"domain_scores_gemma":[0.9998463,0.00002301421,0.00005535974,0.00001911482,0.0000155376,0.00004075273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005915118,0.00001090896,0.000130949,0.0000187983,0.00000162688,0.0000421595,0.000005039255,0.00002933783,0.9992369,0.00005704545,0.00002033227,0.0003876607],"study_design_scores_gemma":[0.00001682727,0.0001467126,0.008667124,0.000006910089,0.000005914476,0.000421327,0.00002242899,0.001039486,0.9874399,0.00004651807,0.002183152,0.000003708056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940611,0.001311652,0.002528909,0.00008277491,0.00002901353,0.00002663808,0.0002916997,0.00009783358,0.001570328],"genre_scores_gemma":[0.9956282,0.00028454,0.001645508,0.00002787246,0.000007341178,0.00002700974,0.0006538178,0.00001962884,0.001706057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133905,"threshold_uncertainty_score":0.004479587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817692678306491,"score_gpt":0.2439551646522731,"score_spread":0.2257782378692082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}