{"id":"W2499543174","doi":"10.1158/1538-7445.am2016-2922","title":"Abstract 2922: Loss of retinoblastoma protein dysregulates HIF1-mediated genetic programs, and promotes tumor cell invasiveness and neuroendocrine differentiation in prostate cancer cells","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; University of British Columbia; Simon Fraser University","funders":"","keywords":"Aryl hydrocarbon receptor nuclear translocator; Neuroendocrine differentiation; Biology; Cancer research; LNCaP; Retinoblastoma protein; Metastasis; Protein kinase B; Prostate cancer; Cell biology; Transcription factor; Signal transduction; Cancer; Cell cycle; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009488865,0.0002625325,0.0002652897,0.0002092972,0.000168158,0.0002979738,0.0001503698,0.0001619553,0.002395034],"category_scores_gemma":[0.00005126077,0.0001283141,0.0002239544,0.0002062403,0.0001671632,0.00008703149,0.0001504159,0.0004004503,0.0008761549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002713556,"about_ca_system_score_gemma":0.0002451473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001849665,"about_ca_topic_score_gemma":0.001765053,"domain_scores_codex":[0.9998664,0.00001651483,0.00001039743,0.00002502454,0.00004790818,0.00003376977],"domain_scores_gemma":[0.9999428,0.000006160429,0.00001431471,0.000008009925,0.000005194036,0.00002353705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004544148,0.00002160788,0.0001026375,0.00001748449,0.000003342275,0.00004318057,0.000007221333,0.0000331902,0.9991987,0.00003967925,0.0000597814,0.0004277772],"study_design_scores_gemma":[0.0000238312,0.0004234571,0.01005721,0.000004937409,0.00001653832,0.000464994,0.00003863754,0.0009361376,0.9826515,0.00002830251,0.005347507,0.000007024826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918143,0.002346957,0.001653184,0.0001480857,0.00005331478,0.00004257444,0.0011646,0.0001912362,0.002585802],"genre_scores_gemma":[0.9901716,0.0009036569,0.000679973,0.00006738854,0.0000133633,0.00004138981,0.00131518,0.00003745793,0.006769966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002395034,"threshold_uncertainty_score":0.008012176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618265521470905,"score_gpt":0.2856555323194923,"score_spread":0.2694728771047832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}