{"id":"W2499836862","doi":"10.1371/journal.pone.0158047","title":"Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Centre for the Replacement, Refinement and Reduction of Animals in Research; Newcastle University; National Institute for Health and Care Research; Wellcome Trust; University of Utah; Biogen","keywords":"SMAD; Integrin; Biology; Downregulation and upregulation; Cell biology; Integrin, beta 6; Chromatin immunoprecipitation; Transforming growth factor; Fibrosis; Transforming growth factor beta; Regulation of gene expression; Molecular biology; Transcriptional regulation; Gene expression; Cancer research; Promoter; Gene; Receptor; Internal medicine; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053794,0.0002195,0.0001430558,0.0002092616,0.000118535,0.0002162564,0.00007867888,0.0002106148,0.002682427],"category_scores_gemma":[0.00009439553,0.0001119584,0.0002974609,0.00009107052,0.0001992262,0.0001047573,0.0001792367,0.0004880897,0.0004276588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000172227,"about_ca_system_score_gemma":0.0001206625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00026626,"about_ca_topic_score_gemma":0.0005479433,"domain_scores_codex":[0.9998994,0.00001652414,0.000004695879,0.0000174239,0.00002761533,0.00003435905],"domain_scores_gemma":[0.9999018,0.00002082427,0.00002867543,0.000008788436,0.00001209472,0.00002787669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000800845,0.00001353084,0.0004790602,0.00003808477,0.00000278689,0.00006827255,0.00001173501,0.00002428869,0.9983156,0.00008477895,0.00003230773,0.0008495028],"study_design_scores_gemma":[0.00004059061,0.0005201518,0.05557534,0.00003405974,0.00003200307,0.0008621825,0.0001161061,0.00110907,0.9350131,0.0002689745,0.006422359,0.000006185438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910251,0.002541209,0.003395761,0.0002334607,0.00005016238,0.00002273088,0.00025852,0.0001198041,0.002353206],"genre_scores_gemma":[0.9939026,0.001397009,0.00119426,0.00009501545,0.00001731578,0.00002597169,0.000365407,0.00001513662,0.002987286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002682427,"threshold_uncertainty_score":0.008973598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05109974954501784,"score_gpt":0.2469792122356915,"score_spread":0.1958794626906737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}