{"id":"W2500114293","doi":"10.1016/j.cardfail.2016.06.113","title":"Pharmacokinetics/Pharmacodynamics, Efficacy and Safety of Sacubitril/Valsartan Versus Enalapril in Pediatric Patients with Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction: Study Design and Rationale","year":2016,"lang":"en","type":"article","venue":"Journal of Cardiac Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Sacubitril, Valsartan; Sacubitril; Valsartan; Enalapril; Internal medicine; Clinical endpoint; Cardiology; Heart failure; Randomized controlled trial; Angiotensin-converting enzyme; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00589622,0.001572241,0.003286347,0.0003879082,0.0005713298,0.001151356,0.0008852354,0.001084567,0.002349436],"category_scores_gemma":[0.005830683,0.0009011749,0.001744951,0.0007256662,0.002336739,0.001350467,0.0004891789,0.002553447,0.0004518134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001055806,"about_ca_system_score_gemma":0.002549815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004983406,"about_ca_topic_score_gemma":0.0007483606,"domain_scores_codex":[0.994956,0.003355525,0.0003496286,0.0004925809,0.0004595321,0.0003867879],"domain_scores_gemma":[0.9975732,0.0009829105,0.0005572079,0.0002924524,0.0001760879,0.0004180649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.910915,0.0114091,0.02504409,0.000728239,0.002076442,0.0002850212,0.0003064144,0.001903075,0.01184605,0.001204176,0.0005426513,0.03373979],"study_design_scores_gemma":[0.3457415,0.5768714,0.05187305,0.0001266489,0.004726328,0.0006356575,0.0002520492,0.004045987,0.008923667,0.001252332,0.005424127,0.0001271679],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9860853,0.002566645,0.002194906,0.0003767427,0.0001225184,0.006019043,0.0008514487,0.00004001355,0.001743364],"genre_scores_gemma":[0.9835671,0.001437913,0.004769635,0.0004457837,0.0003265722,0.008271812,0.0005007308,0.00002616146,0.0006542511],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.00589622,"threshold_uncertainty_score":0.03118259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00991002470937545,"score_gpt":0.2496716014841649,"score_spread":0.2397615767747894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}