{"id":"W2500169107","doi":"10.1124/jpet.116.234096","title":"Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; Canadian Institutes of Health Research; Crohn's and Colitis Foundation","keywords":"Pregnane X receptor; Myosin light-chain kinase; Barrier function; Inflammation; Cell biology; Biology; IκB kinase; Tight junction; Kinase; TLR4; Tumor necrosis factor alpha; Signal transduction; Proinflammatory cytokine; Chemistry; Cancer research; Endocrinology; Transcription factor; Nuclear receptor; Biochemistry; Immunology; NF-κB; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004059537,0.0002078726,0.000284963,0.0001721482,0.0001936523,0.00002110888,0.00005591944,0.0001878694,0.0001622924],"category_scores_gemma":[0.0001608256,0.0001444792,0.0000578874,0.0001025119,0.0001139411,0.0005586823,0.00003332513,0.0002952377,0.000002855012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002375951,"about_ca_system_score_gemma":0.0001282232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002631857,"about_ca_topic_score_gemma":1.404488e-7,"domain_scores_codex":[0.9985781,0.0002114875,0.0005276834,0.0001963955,0.0002643496,0.0002220259],"domain_scores_gemma":[0.9986594,0.0002312682,0.000671392,0.00006106884,0.000189739,0.0001871768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002025987,0.0002896079,0.0006814899,0.00002552309,0.000119619,0.00001113361,0.001166421,4.601378e-7,0.9687746,0.000005794787,0.000510758,0.02638863],"study_design_scores_gemma":[0.00698829,0.001431288,0.0005120314,0.001263418,0.0001358563,0.000132196,0.0004863202,0.00007924809,0.9875253,0.00003964562,0.001251006,0.0001553502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935034,0.0004806097,0.000855153,0.004395113,0.0004050971,0.0002947521,0.00001062077,0.0000218109,0.00003342478],"genre_scores_gemma":[0.9980586,0.0002917088,0.0002426876,0.0007287238,0.0004920467,0.00001985882,0.00001676508,0.00002152704,0.000128097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02623328,"threshold_uncertainty_score":0.5891691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02163708179018465,"score_gpt":0.3154132621678499,"score_spread":0.2937761803776653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}