{"id":"W2500169107","doi":"10.1124/jpet.116.234096","title":"Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; Canadian Institutes of Health Research; Crohn's and Colitis Foundation","keywords":"Pregnane X receptor; Myosin light-chain kinase; Barrier function; Inflammation; Cell biology; Biology; IκB kinase; Tight junction; Kinase; TLR4; Tumor necrosis factor alpha; Signal transduction; Proinflammatory cytokine; Chemistry; Cancer research; Endocrinology; Transcription factor; Nuclear receptor; Biochemistry; Immunology; NF-κB; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002127102,0.0003896951,0.0004737267,0.0002478297,0.0003032546,0.0003612967,0.0002766668,0.0003132125,0.003580777],"category_scores_gemma":[0.0002436702,0.0002104446,0.0003907668,0.000157254,0.0005468323,0.0004115584,0.0003135746,0.001499291,0.000437443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002415354,"about_ca_system_score_gemma":0.0008534197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005466713,"about_ca_topic_score_gemma":0.001031098,"domain_scores_codex":[0.9997764,0.00005150094,0.00001602881,0.00002425752,0.00003899336,0.00009286221],"domain_scores_gemma":[0.9998889,0.00001169411,0.00003135111,0.00001263107,0.000008799956,0.00004654874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008296859,0.000706191,0.0003370847,0.0002681833,0.00004557084,0.0002508567,0.00008353821,0.0001032448,0.9796488,0.0005699096,0.0002910528,0.009398781],"study_design_scores_gemma":[0.001253163,0.006066232,0.01068995,0.00005477171,0.0001904598,0.0006577906,0.0003525767,0.001300288,0.9708292,0.0004765558,0.008104022,0.00002493466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910575,0.004298782,0.001460794,0.0004677039,0.0001817314,0.00006138528,0.0001258653,0.000116579,0.002229665],"genre_scores_gemma":[0.9898152,0.003168278,0.0010053,0.0001153887,0.00005528577,0.00008986398,0.0002016952,0.00001883364,0.005530138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003580777,"threshold_uncertainty_score":0.01197892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02163708179018465,"score_gpt":0.3154132621678499,"score_spread":0.2937761803776653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}