{"id":"W2500942359","doi":"10.1016/j.aca.2016.08.006","title":"Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review","year":2016,"lang":"en","type":"review","venue":"Analytica Chimica Acta","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"Krembil Foundation; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Mitacs; Ontario Ministry of Research, Innovation and Science","keywords":"Chemistry; Hydrogen–deuterium exchange; Biopharmaceutical; Biosimilar; Mass spectrometry; Bioanalysis; Monoclonal antibody; Nanotechnology; Computational biology; Biochemical engineering; Chromatography; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000336789,0.0007329845,0.002131673,0.0004432813,0.00007745583,0.00009361106,0.0007394569,0.0004052927,0.00507605],"category_scores_gemma":[0.00006989946,0.0005431469,0.0003907428,0.0007752681,0.0001256591,0.0001439022,0.0004208,0.0006784116,0.0001135096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000490518,"about_ca_system_score_gemma":0.0002670458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002056668,"about_ca_topic_score_gemma":0.000002527905,"domain_scores_codex":[0.9967394,0.00006054459,0.001119865,0.001034654,0.000342916,0.0007025574],"domain_scores_gemma":[0.9981232,0.000223955,0.0003980357,0.0009538479,0.0000260173,0.0002749331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001833494,0.0006257045,0.00006388868,0.261891,0.00140698,0.0001373437,0.00002790238,6.745723e-10,0.004739303,0.003094703,0.006790309,0.7212046],"study_design_scores_gemma":[0.0001433072,0.000009755769,0.000002135828,0.03218938,0.0005076502,0.0000813029,0.000001636568,0.000002523571,0.000637136,0.0001761629,0.9655859,0.0006630675],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001843308,0.9829953,0.00002285029,0.0006127809,0.00001895773,0.0005766076,0.0001652257,0.0001357549,0.01545404],"genre_scores_gemma":[0.0001620333,0.995267,0.001799123,0.0001770037,0.0001829549,0.0004914214,0.0002160435,0.0001025156,0.001601942],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9587956,"threshold_uncertainty_score":0.999702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04220996986565415,"score_gpt":0.3399706601722977,"score_spread":0.2977606903066435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}