{"id":"W2501056827","doi":"10.1021/acs.jmedchem.6b00855","title":"Structure–Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Structural Genomics Consortium; National Institute of General Medical Sciences; Wellcome Trust; Wellcome","keywords":"EZH2; Chemistry; Enhancer; Structure–activity relationship; In vitro; Biochemistry; Methylation; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003766885,0.0006053039,0.0006652004,0.0003240921,0.0002421869,0.0002607872,0.0006236064,0.0003058293,0.002794225],"category_scores_gemma":[0.000289363,0.0002458449,0.0005931674,0.0005165307,0.000163907,0.0003896315,0.0002141826,0.0007556288,0.0004218099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000512896,"about_ca_system_score_gemma":0.0003945957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00160042,"about_ca_topic_score_gemma":0.002961961,"domain_scores_codex":[0.9998229,0.000046224,0.00001069833,0.00002708701,0.00004523864,0.00004784044],"domain_scores_gemma":[0.9998783,0.00003623315,0.00003216772,0.000008703406,0.00002452509,0.00002001355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003155397,0.002384126,0.001895549,0.0008515388,0.0002918819,0.0005507625,0.0001676723,0.02025871,0.9366558,0.0013921,0.002483773,0.02991277],"study_design_scores_gemma":[0.001561183,0.02759067,0.0115182,0.00006736142,0.0008002832,0.001487979,0.0001867496,0.03224834,0.8897656,0.0006440294,0.03400557,0.0001239513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562999,0.02620268,0.004200672,0.0005244085,0.00009390633,0.0002435996,0.001965954,0.0001288129,0.01034013],"genre_scores_gemma":[0.9759187,0.01382213,0.003757864,0.0002538496,0.0000369391,0.00007979325,0.002388675,0.00001531956,0.00372663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002794225,"threshold_uncertainty_score":0.009347677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258472865856553,"score_gpt":0.3159433002242339,"score_spread":0.2933585715656684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}