{"id":"W2501335509","doi":"10.1124/mol.116.104687","title":"A Fibroblast Growth Factor 21–Pregnane X Receptor Pathway Downregulates Hepatic CYP3A4 in Nonalcoholic Fatty Liver Disease","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Pregnane X receptor; CYP3A4; Nonalcoholic fatty liver disease; FGF21; Pregnane; Internal medicine; Endocrinology; Receptor; Fibroblast growth factor; Fatty liver; Chemistry; Disease; Biology; Medicine; Gene; Biochemistry; Nuclear receptor; Transcription factor; Metabolism; Cytochrome P450; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780028,0.0002860708,0.0003465966,0.0003884225,0.00026919,0.0002990997,0.0001336604,0.0002330421,0.002042708],"category_scores_gemma":[0.0001950522,0.000208618,0.0003537764,0.0001859628,0.0002858783,0.0001510985,0.0002019988,0.0005140515,0.0002756345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003665268,"about_ca_system_score_gemma":0.0002664009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001501979,"about_ca_topic_score_gemma":0.002332146,"domain_scores_codex":[0.9998649,0.00003711621,0.00001326585,0.00001523056,0.00003431435,0.00003519005],"domain_scores_gemma":[0.9999114,0.00001128075,0.00001666706,0.00001215624,0.0000138623,0.0000346031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003484662,0.0001004704,0.002155283,0.00004728021,0.0000403876,0.0002985606,0.00002229486,0.00006881008,0.9893008,0.0001843889,0.0001059107,0.004191148],"study_design_scores_gemma":[0.0005357333,0.001420736,0.1031237,0.00001319936,0.0002243781,0.001111912,0.000169679,0.0009980116,0.8881916,0.0003920544,0.003804449,0.00001457741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968034,0.001434455,0.0006723864,0.0001528527,0.00003948752,0.00001182311,0.0000875917,0.00004036335,0.0007575895],"genre_scores_gemma":[0.9964535,0.000547677,0.0004343841,0.0000610583,0.00001614456,0.00002143773,0.000151544,0.000009933237,0.002304228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002042708,"threshold_uncertainty_score":0.006833553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103778550670405,"score_gpt":0.2644770787828422,"score_spread":0.2534392932761382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}