{"id":"W2501460328","doi":"10.1158/1538-7445.am2016-2302","title":"Abstract 2302: An ‘off the shelf,’ GMP-grade, IL-2-independent NK cell line expressing the high-affinity Fc-receptor to augment antibody therapeutics","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Antibody-dependent cell-mediated cytotoxicity; CD16; Fc receptor; Molecular biology; Transfection; Antibody; Monoclonal antibody; Biology; Population; Cell culture; Receptor; Natural killer cell; Cancer research; Immunology; Cytotoxicity; Medicine; Antigen; CD3; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993918,0.0004023201,0.0003228816,0.0001973895,0.0001465668,0.0003891284,0.000402795,0.0003860425,0.003361019],"category_scores_gemma":[0.0001410421,0.0001714072,0.0002262207,0.0002394826,0.0001689077,0.000238085,0.0002155485,0.0009741593,0.003103353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002477945,"about_ca_system_score_gemma":0.0002362025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005390933,"about_ca_topic_score_gemma":0.0006234335,"domain_scores_codex":[0.9997539,0.00003478736,0.00002627716,0.00004828871,0.00009996279,0.00003683371],"domain_scores_gemma":[0.9998858,0.00001795362,0.00001851332,0.00002746433,0.00002502586,0.00002528878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001312631,0.0001081702,0.0001299227,0.00002489099,0.000005127092,0.0001017129,0.00001928769,0.0001051646,0.9970168,0.0001743579,0.0004133382,0.001770023],"study_design_scores_gemma":[0.0001251668,0.0009841752,0.002585255,0.00001004163,0.00003634716,0.001646791,0.00002263295,0.001817124,0.9635088,0.00006866835,0.02918404,0.00001100976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562731,0.002183188,0.01832757,0.0007195669,0.0002980994,0.0005950708,0.00569646,0.0005310662,0.01537594],"genre_scores_gemma":[0.9332787,0.001161258,0.02177113,0.0002767709,0.00006191609,0.0003314103,0.01283327,0.0001545971,0.03013092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003361019,"threshold_uncertainty_score":0.0112437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1290910178363738,"score_gpt":0.4428023051668808,"score_spread":0.3137112873305071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}