{"id":"W2501927824","doi":"10.1038/srep30918","title":"ATF3 controls proliferation of osteoclast precursor and bone remodeling","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Osteoclast; RANKL; Bone resorption; Activating transcription factor; ATF3; Bone remodeling; Cell biology; Precursor cell; Bone marrow; Transcription factor; RANK Ligand; Activator (genetics); Endocrinology; Cancer research; Internal medicine; Chemistry; Biology; Medicine; Cell; Receptor; Gene expression; Unfolded protein response; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000160248,0.0003650331,0.0002505979,0.0002999865,0.0002749407,0.0002701915,0.0002127429,0.0003214847,0.0009621768],"category_scores_gemma":[0.0001062827,0.0001378277,0.0003150306,0.0001979083,0.0003438154,0.000222011,0.0002945724,0.0003662633,0.0002651406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339463,"about_ca_system_score_gemma":0.0003484313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009409743,"about_ca_topic_score_gemma":0.001057729,"domain_scores_codex":[0.9998635,0.00001659025,0.00001055097,0.00002720803,0.00003789577,0.00004414278],"domain_scores_gemma":[0.9999331,0.000004128153,0.0000215303,0.000005403941,0.00001084247,0.00002490559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003243084,0.0000186299,0.0005318106,0.0000554003,0.00000531438,0.0001026905,0.00002070983,0.00004845533,0.995481,0.0003051283,0.00008093619,0.003025559],"study_design_scores_gemma":[0.00007384467,0.0003002664,0.02876571,0.00002628482,0.00005195988,0.00131934,0.0001150873,0.001386816,0.9538166,0.0008425628,0.01328233,0.0000193579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974305,0.01163099,0.00849224,0.0002760603,0.0001003769,0.00003502463,0.0009293793,0.0002562446,0.003974695],"genre_scores_gemma":[0.9929925,0.002292368,0.002425484,0.00006553502,0.00001924174,0.00001916884,0.0004342216,0.00002195955,0.001729453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009621768,"threshold_uncertainty_score":0.00321877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007898082444529624,"score_gpt":0.2272189710837543,"score_spread":0.2193208886392247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}