{"id":"W2501927824","doi":"10.1038/srep30918","title":"ATF3 controls proliferation of osteoclast precursor and bone remodeling","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Osteoclast; RANKL; Bone resorption; Activating transcription factor; ATF3; Bone remodeling; Cell biology; Precursor cell; Bone marrow; Transcription factor; RANK Ligand; Activator (genetics); Endocrinology; Cancer research; Internal medicine; Chemistry; Biology; Medicine; Cell; Receptor; Gene expression; Unfolded protein response; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000421716,0.00007207833,0.0001118973,0.0000362317,0.00006819115,0.00003650405,0.00003348295,0.0000489173,0.00001017359],"category_scores_gemma":[0.0002457207,0.00004838471,0.00004414993,0.000049229,0.0001551373,0.000009084631,0.0000478013,0.00001280803,0.000001761462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002392676,"about_ca_system_score_gemma":0.00008439714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002203664,"about_ca_topic_score_gemma":0.000006899844,"domain_scores_codex":[0.99906,0.00002565925,0.0002613772,0.0003809843,0.0001481424,0.0001238217],"domain_scores_gemma":[0.9992505,0.000005990079,0.0001567445,0.0003723202,0.0001423952,0.00007208922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003791495,0.00002439006,0.006271912,0.00001190064,0.000006197077,0.000004602005,0.00001494448,0.00000446471,0.9857799,0.00004167088,0.001923242,0.005878882],"study_design_scores_gemma":[0.0004731658,0.00006137371,0.00294706,0.00004218754,0.00003063491,0.00009264319,0.00001391101,0.00004192716,0.9503356,0.001927855,0.04389782,0.0001357852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953354,0.001988569,0.001286514,0.00009219885,0.0007219288,0.0001912237,0.00000972701,0.000007700563,0.0003667357],"genre_scores_gemma":[0.9972831,0.00003432504,0.0003267764,0.00001769145,0.00008419174,0.00001167499,0.00003110507,0.000006755281,0.00220438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04197458,"threshold_uncertainty_score":0.1973071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007898082444529624,"score_gpt":0.2272189710837543,"score_spread":0.2193208886392247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}