{"id":"W2501981640","doi":"10.1093/jac/dkw246","title":"Surotomycin versus vancomycin for<i>Clostridium difficile</i>infection: Phase 2, randomized, controlled, double-blind, non-inferiority, multicentre trial","year":2016,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; University of Calgary; McMaster University; Hamilton Regional Laboratory Medicine Program; Royal Jubilee Hospital; St. Joseph’s Healthcare Hamilton; Island Health","funders":"Viropharma; Merck","keywords":"Medicine; Vancomycin; Clostridium difficile; Adverse effect; Internal medicine; Antibiotics; Randomized controlled trial; Incidence (geometry); Clinical trial; Surgery; Diarrhea; Antibacterial agent; Gastroenterology; Anesthesia; Staphylococcus aureus; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002299639,0.0006336457,0.003537822,0.0005961812,0.0002211212,0.0001433682,0.0003420656,0.0004070428,0.0005815269],"category_scores_gemma":[0.0008672694,0.0003857283,0.002840935,0.0004426318,0.0003312706,0.0002899335,0.00006016379,0.000626119,0.0000409611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004845816,"about_ca_system_score_gemma":0.001059052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005748085,"about_ca_topic_score_gemma":0.00002027112,"domain_scores_codex":[0.9951982,0.0002298183,0.002283696,0.0005066877,0.0009180109,0.0008636144],"domain_scores_gemma":[0.9942182,0.00188477,0.001352348,0.0005246226,0.001493512,0.0005265172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7033706,0.002358137,0.00003071796,0.00008493492,0.001322537,0.00006833149,0.00007651567,0.000004227671,0.280124,0.00001740591,0.008598476,0.003944065],"study_design_scores_gemma":[0.6027206,0.00283195,0.00000206094,0.0002690191,0.0006248463,0.0001427948,0.00001785256,0.00005523031,0.3836846,0.000006204464,0.009382714,0.0002621664],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738436,0.000220403,0.003393879,0.009260285,0.003728581,0.008870516,0.00005329944,0.00005686576,0.0005725577],"genre_scores_gemma":[0.9874701,0.003930459,0.0008434994,0.0003952525,0.005769416,0.0001476233,0.00001893717,0.0001322368,0.001292459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1035606,"threshold_uncertainty_score":0.9998595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04132298690798683,"score_gpt":0.3625863414447916,"score_spread":0.3212633545368048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}